low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
#retatrutide 2026-04-12
Sunday58 messages11 participantstimes are UTC
Highlights from this day
- u100_pat — i log resting heart rate every morning because of this and its the one number i actually watch, your mileage will differ 04:02
- lisbon_lot — stepping in 1 increments instead of doubling is the only thing i would change if i started again 05:42
- lisbon_lot — Medutest came back 98.6 on one lot and 98.1 on the next from the same ERP, both fine, anyway 06:03
- lisbon_lot — is TRIUMPH the phase 3 programme 06:09
- declared_value — sat at 0.5 for 3 months rather than climbing and it kept working, so i never went up, thats just me 07:24
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
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anyone reconstituting 15 vials to 2.5 so the steps come out smaller
reconstituted the 5 vial to 10mg/ml specifically so i could take 0.5 without measuring crumbs
held mine ages
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
my resting heart rate is up about 9 bpm, did that settle for anyone
anyone logging resting heart rate on this
settled by month three
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phase 2 only
slightly off topic but back after 9 months, has anything actually been published since
triple agonist yeah
glucagon is the new bit
people insist on small steps because the side effects arrive faster than on the other two
no idea whether the heart rate settles for everyone, mine did and one log isnt data
sorry to jump in the heart rate thing is real enough that i mention it whenever someone asks about starting
bac_water_billslightly off topic but back after 9 months, has anything actually been published since
anyone tracking blood pressure alongside the heart rate
the honest position is this has less human evidence behind it than anything else discussed here
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
how do people square the research use only framing with logging their own use
unrelated but stopped for 24 months and restarted at half my old dose, the ramp was easier second time, your mileage will differ
research use only
janoshik-a-2601.pdf
2 pages · 108 KB · not retained in the public archive
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
i log resting heart rate every morning because of this and its the one number i actually watch, your mileage will differ
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does the energy expenditure claim show up as anything you can feel
im at 2.4 and the appetite effect is stronger than i expected, normal
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
sorry to jump in phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
stepping in 1 increments instead of doubling is the only thing i would change if i started again
fridge-temps.csv
679 rows · not retained in the public archive
held at 12 for 22 months and it never plateaued for me, which i cant explain
appetite suppression at 15 was stronger than my tirzepatide experience at a comparable point
Medutest came back 98.6 on one lot and 98.1 on the next from the same ERP, both fine, anyway
[edited]no long term data
smaller steps here
is TRIUMPH the phase 3 programme
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logging rhr daily
weights-monthly.csv
385 rows · not retained in the public archive
nobody should read my log as a plan, im recording what i did and thats all it is, i think
how slow is low and slow here, four weeks a step or longer
watching my heart rate
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
blood pressure stayed flat for me while heart rate moved, which i didnt expect
low and slow
[edited]is there any long term safety data at all or is it phase 2 and hope
my resting rate went up 5 bpm in the first month and came back most of the way by month 26
genuine question whats the half life like, is it weekly the same way
coming back to this does the glucagon arm explain the heart rate or is that unrelated
lost 7kg over 7 months at doses well under what the trials used
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely, i could be wrong
the purity spread across lots worries me more than the molecule does
came off at 28 weeks because my resting rate stayed elevated and i didnt like it
GI was about the same as tirzepatide for me, the difference was how fast it arrived
TRIUMPH is phase 3
i said 5 months ago that my heart rate had settled and it has stayed settled since
held at 7.5 for 26 months and it never plateaued for me, which i cant explain
mine went up too
the purity spread across lots worries me more than the molecule does
is the phase 2 dosing anywhere near what people here run
sat at 0.5 for 3 months rather than climbing and it kept working, so i never went up, thats just me
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