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#retatrutide 2026-04-16

Thursday50 messages9 participantstimes are UTC
Highlights from this day
  • vat_on_import — i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps 22:03
  • nhs_pathway_nell — did the phase 2 plateau or was it still moving at the end i log resting heart rate every morning because of this and its the one number i actually watch 22:16
  • rotate_the_site — stepping in 1.7 increments instead of doubling is the only thing i would change if i started again 22:22
  • sorrel_sends — i log resting heart rate every morning because of this and its the one number i actually watch 23:07
  • triumph_watch — the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial 23:12

triple agonist meaning GLP-1, GIP and glucagon, have i got that right

CH

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, thats just me

lost 34kg over 1 months at doses well under what the trials used

slightly off topic but there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

🧪11
KK

blood pressure stayed flat for me while heart rate moved, which i didnt expect

how slow is low and slow here, four weeks a step or longer

smaller steps here

TRIUMPH is phase 3

🧊17

the heart rate thing is real enough that i mention it whenever someone asks about starting

*PeptideMeter not the other one

held mine ages

TW

Janoshik came back 99.2 on one lot and 98.1 on the next from the same CPC, both fine, take that with a pinch of salt

came off at 29 weeks because my resting rate stayed elevated and i didnt like it

22:07chlorhex pinned a message
RT

phase 2 was still trending at the end which is why the phase 3 readout matters more than usual

NP

slightly off topic but the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

did the phase 2 plateau or was it still moving at the end
i log resting heart rate every morning because of this and its the one number i actually watch

🙏6😂4

glucagon is the new bit

*VendorInvestigate not the other one

RT

stepping in 1.7 increments instead of doubling is the only thing i would change if i started again

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, ill dig out the number

mine went up too

[edited]
SS

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

coa-sg-1177.pdf
1 page · 266 KB · not retained in the public archive

triple agonist yeah

anyone gone above 0.25 and what changed

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

🙏5
VO

buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely

cant feel it honestly

right so whats the half life like, is it weekly the same way

GI was about the same as tirzepatide for me, the difference was how fast it arrived, i could be wrong

SS

stopped for 7 months and restarted at half my old dose, the ramp was easier second time

sat at 5 for 9 months rather than climbing and it kept working, so i never went up

appetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point, take that with a pinch of salt

i log resting heart rate every morning because of this and its the one number i actually watch

coa-f-1330.pdf
1 page · 767 KB · not retained in the public archive
😂5
TW

genuine question is the GI worse than tirzepatide or about the same

coa-kp-0925.pdf
1 page · 762 KB · not retained in the public archive

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial

📉15

im at 10 and the appetite effect is stronger than i expected, normal

23:25chlorhex pinned a message
TW

nobody should read my log as a plan, im recording what i did and thats all it is