did anyone come off because of the heart rate
#retatrutide 2026-04-15
Wednesday45 messages9 participantstimes are UTC
Highlights from this day
- elder_eu — held at 2 for 25 months and it never plateaued for me, which i cant explain 20:00
- turnaround_tam — low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom 20:14
- turnaround_tam — stopped for 11 months and restarted at half my old dose, the ramp was easier second time, we shall see 20:47
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
watching my heart rate
held mine ages
mine went up too
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
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cant feel it honestly
is there any long term safety data at all or is it phase 2 and hope
the honest position is this has less human evidence behind it than anything else discussed here
logging rhr daily
phase 2 only
smaller steps here
glucagon is the new bit
[edited]lost 45kg over 25 months at doses well under what the trials used
is the GI worse than tirzepatide or about the same
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
held at 2 for 25 months and it never plateaued for me, which i cant explain
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low and slow
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
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how do people square the research use only framing with logging their own use
research use only
the half life supports weekly dosing and thats what ive done from the start, thats one data point
blood pressure stayed flat for me while heart rate moved, which i didnt expect
the purity spread across lots worries me more than the molecule does
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
stopped for 11 months and restarted at half my old dose, the ramp was easier second time, we shall see
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)the heart rate thing is real enough that i mention it whenever someone asks about starting, not advice obviously
On this day 7 years ago this channel logged 92 messages.
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how long before people saw the first change at 1.7
does the energy expenditure claim show up as anything you can feel
unrelated but is TRIUMPH the phase 3 programme
sat at 5 for 6 months rather than climbing and it kept working, so i never went up
anyone logging resting heart rate on this
quick one i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
anyone reconstituting 5 vials to 10 so the steps come out smaller
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, still working it out
TRIUMPH is phase 3
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came off at 10 weeks because my resting rate stayed elevated and i didnt like it
no long term data
triple agonist yeah
anyone compared their VendorInvestigate purity across two different SGN lots
settled by month three
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i log resting heart rate every morning because of this and its the one number i actually watch
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
anyone tracking blood pressure alongside the heart rate