On this day 6 years ago this channel logged 88 messages.
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#retatrutide 2026-04-26
Sunday59 messages13 participantstimes are UTC
Highlights from this day
- VialBot — On this day 6 years ago this channel logged 88 messages. 19:31
- reta_resting_hr — update on the earlier thing i log resting heart rate every morning because of this and its the one number i actually watch, i could be wrong 19:40
- thirty_one_g — there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists 22:04
- lot_number_lou — came off at 13 weeks because my resting rate stayed elevated and i didnt like it 23:05
my resting rate went up 6 bpm in the first month and came back most of the way by month 25
sat at 2.4 for 5 months rather than climbing and it kept working, so i never went up
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update on the earlier thing i log resting heart rate every morning because of this and its the one number i actually watch, i could be wrong
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did anyone come off because of the heart rate
phase 2 only
did the phase 2 plateau or was it still moving at the end
anyone compared their Medutest purity across two different QYB lots
settled by month three
sorry to jump in the honest position is this has less human evidence behind it than anything else discussed here, for what its worth
GI was about the same as tirzepatide for me, the difference was how fast it arrived
anyone reconstituting 10 vials to 2.5 so the steps come out smaller
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mine went up too
TRIUMPH is phase 3
unrelated but blood pressure stayed flat for me while heart rate moved, which i didnt expect
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logging rhr daily
no long term data
ok so stepping in 0.25 increments instead of doubling is the only thing i would change if i started again
*PeptideMeter not the other one
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
the purity spread across lots worries me more than the molecule does
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
slightly off topic but appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point
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i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
lost 44kg over 11 months at doses well under what the trials used
triple agonist yeah
whats a sensible starting point, im seeing everything from 0.5 to 2
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
sorry to jump in low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
im at 2.4 and the appetite effect is stronger than i expected, normal
stopped for 3 months and restarted at half my old dose, the ramp was easier second time
no idea whether the heart rate settles for everyone, mine did and one log isnt data
unrelated but research use only is on every vial and i treat it as exactly that, nobody here is prescribing, still working it out
the half life supports weekly dosing and thats what ive done from the start
did the phase 2 result actually come in higher than the tirzepatide numbers
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
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whats the half life like, is it weekly the same way
how do people square the research use only framing with logging their own use
is the glucagon arm what people mean by the energy expenditure thing
how slow is low and slow here, four weeks a step or longer
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
is the phase 2 dosing anywhere near what people here run
mine went up too
held mine ages
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
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coming back to this nobody should read my log as a plan, im recording what i did and thats all it is
research use only
low and slow
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smaller steps here
cant feel it honestly
watching my heart rate
the heart rate thing is real enough that i mention it whenever someone asks about starting
does the glucagon arm explain the heart rate or is that unrelated
how long before people saw the first change at 12
the heart rate thing is real enough that i mention it whenever someone asks about starting
Janoshik came back 99.2 on one lot and 99 on the next from the same TFC, both fine, from memory
came off at 13 weeks because my resting rate stayed elevated and i didnt like it
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*week 10 not week 8
is the GI worse than tirzepatide or about the same
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, n of 1 obviously
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