is the glucagon arm what people mean by the energy expenditure thing
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
#retatrutide 2026-05-09
Saturday27 messages9 participantstimes are UTC
Highlights from this day
- no_escrow_nate — the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial 17:54
- amylin_amy — research use only is on every vial and i treat it as exactly that, nobody here is prescribing 17:57
- VialBot — Testing queue: 5 submissions open, 123 awaiting dispatch. 18:14
no idea whether the heart rate settles for everyone, mine did and one log isnt data
appetite suppression at 1 was stronger than my tirzepatide experience at a comparable point
sorry to jump in buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
no long term data
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)research use only is on every vial and i treat it as exactly that, nobody here is prescribing
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the honest position is this has less human evidence behind it than anything else discussed here
[edited]im at 1.7 and the appetite effect is stronger than i expected, normal
Testing queue: 5 submissions open, 123 awaiting dispatch.
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anyone reconstituting 2 vials to 8 so the steps come out smaller
i log resting heart rate every morning because of this and its the one number i actually watch
came off at 25 weeks because my resting rate stayed elevated and i didnt like it
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
is TRIUMPH the phase 3 programme
cant feel it honestly
stepping in 2.4 increments instead of doubling is the only thing i would change if i started again
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*Janoshik not the other one
low and slow
anyone logging resting heart rate on this
back after 25 months, has anything actually been published since
does the energy expenditure claim show up as anything you can feel
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
held mine ages
anyone compared their PeptideMeter purity across two different MKM lots
why does everyone insist on smaller steps here than on the other two