update on the earlier thing Medutest came back 99 on one lot and 96.8 on the next from the same KP, both fine, ymmv
#retatrutide 2026-05-16
Saturday62 messages11 participantstimes are UTC
Highlights from this day
- thank_you_year_on — my resting rate went up 8 bpm in the first month and came back most of the way by month 1 21:25
- alt_ast_ali — im at 0.5 and the appetite effect is stronger than i expected, normal 21:28
- mid_week_mo — held at 15 for 21 months and it never plateaued for me, which i cant explain 22:00
- mid_week_mo — i said 9 months ago that my heart rate had settled and it has stayed settled since 22:23
coming back to this the honest position is this has less human evidence behind it than anything else discussed here
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reconstituted the 15 vial to 2mg/ml specifically so i could take 15 without measuring crumbs
quick one blood pressure stayed flat for me while heart rate moved, which i didnt expect, someone check my working
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
low and slow
stepping in 5 increments instead of doubling is the only thing i would change if i started again
coming back to this is the GI worse than tirzepatide or about the same
right so is there any long term safety data at all or is it phase 2 and hope
whats the half life like, is it weekly the same way
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anyone logging resting heart rate on this
why does everyone insist on smaller steps here than on the other two
my resting heart rate is up about 7 bpm, did that settle for anyone
GI was about the same as tirzepatide for me, the difference was how fast it arrived, from memory
21:19tenpence pinned a message to this channel
phase 2 only
no idea whether the heart rate settles for everyone, mine did and one log isnt data
my resting rate went up 8 bpm in the first month and came back most of the way by month 1
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im at 0.5 and the appetite effect is stronger than i expected, normal
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anyone tracking blood pressure alongside the heart rate
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
did the phase 2 plateau or was it still moving at the end
is the phase 2 dosing anywhere near what people here run
did the phase 2 result actually come in higher than the tirzepatide numbers
unrelated but the half life supports weekly dosing and thats what ive done from the start
[edited]settled by month three
mine went up too
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
anyone gone above 7.5 and what changed
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buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
is the glucagon arm what people mean by the energy expenditure thing
does the energy expenditure claim show up as anything you can feel
held at 15 for 21 months and it never plateaued for me, which i cant explain
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i log resting heart rate every morning because of this and its the one number i actually watch
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
anyone stayed at 15 for months rather than climbing
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i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
does the glucagon arm explain the heart rate or is that unrelated
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
anyone reconstituting 20 vials to 8 so the steps come out smaller
[edited]triple agonist yeah
i said 9 months ago that my heart rate had settled and it has stayed settled since
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)📈1🎉5🧊1
did anyone come off because of the heart rate
anyone compared their Medutest purity across two different ERP lots
watching my heart rate
glucagon is the new bit
cant feel it honestly
coming back to this the purity spread across lots worries me more than the molecule does
appetite suppression at 2 was stronger than my tirzepatide experience at a comparable point
smaller steps here
held mine ages
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
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right so the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
nobody should read my log as a plan, im recording what i did and thats all it is
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unrelated but triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
stopped for 19 months and restarted at half my old dose, the ramp was easier second time
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
back after 24 months, has anything actually been published since
TRIUMPH is phase 3, ask me again in a month