Reminder set. I will post here in 2 days.
#retatrutide 2026-05-19
Tuesday64 messages13 participantstimes are UTC
Highlights from this day
- split_shipment — the heart rate thing is real enough that i mention it whenever someone asks about starting phase 2 was still trending at the end which is why the phase 3 readout… 10:17
- meniscus_mel — whats the half life like, is it weekly the same way 12:29
- meniscus_mel — does the glucagon arm explain the heart rate or is that unrelated 12:30
- split_shipment — ok so no idea whether the heart rate settles for everyone, mine did and one log isnt data 14:17
i log resting heart rate every morning because of this and its the one number i actually watch
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
is the phase 2 dosing anywhere near what people here run
low and slow
settled by month three
nobody should read my log as a plan, im recording what i did and thats all it is
does the energy expenditure claim show up as anything you can feel
research use only
how long before people saw the first change at 2.5
did the phase 2 result actually come in higher than the tirzepatide numbers
anyone logging resting heart rate on this
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
people insist on small steps because the side effects arrive faster than on the other two
whats a sensible starting point, im seeing everything from 0.5 to 2
the purity spread across lots worries me more than the molecule does
update on the earlier thing sat at 0.5 for 2 months rather than climbing and it kept working, so i never went up, we shall see
[edited]the heart rate thing is real enough that i mention it whenever someone asks about starting
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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how slow is low and slow here, four weeks a step or longer
the half life supports weekly dosing and thats what ive done from the start
ok so phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
mine went up too
blood pressure stayed flat for me while heart rate moved, which i didnt expect
VendorInvestigate came back 98.6 on one lot and 99 on the next from the same FGP, both fine
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
*that should say weekly
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
anyone reconstituting 10 vials to 10 so the steps come out smaller
held at 10 for 21 months and it never plateaued for me, which i cant explain
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
sorry to jump in the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
is there any long term safety data at all or is it phase 2 and hope
did the phase 2 plateau or was it still moving at the end
cant feel it honestly
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
stepping in 1.7 increments instead of doubling is the only thing i would change if i started again, ymmv
residual_solventsorry to jump in the phase 2 weight result was larger than what the earlier agonists…
came off at 27 weeks because my resting rate stayed elevated and i didnt like it
whats the half life like, is it weekly the same way
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does the glucagon arm explain the heart rate or is that unrelated
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, someone check my working
*Janoshik not the other one
phase 2 only
did anyone come off because of the heart rate
is the glucagon arm what people mean by the energy expenditure thing
right so my resting heart rate is up about 6 bpm, did that settle for anyone
stopped for 11 months and restarted at half my old dose, the ramp was easier second time
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
glucagon is the new bit
the honest position is this has less human evidence behind it than anything else discussed here
stepping in 10 increments instead of doubling is the only thing i would change if i started again
anyone gone above 12 and what changed
quick one watching my heart rate
ok so no idea whether the heart rate settles for everyone, mine did and one log isnt data
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is the GI worse than tirzepatide or about the same
logging rhr daily
while im here reconstituted the 40 vial to 5mg/ml specifically so i could take 0.25 without measuring crumbs
smaller steps here
GI was about the same as tirzepatide for me, the difference was how fast it arrived
i said 5 months ago that my heart rate had settled and it has stayed settled since
Purity check: no report on file for lot B-0329. Nothing logged either way.
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
how do people square the research use only framing with logging their own use
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, i think
for the archive TRIUMPH is phase 3