triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)#retatrutide 2026-05-23
Saturday62 messages9 participantstimes are UTC
Highlights from this day
- no_chargeback — quick one is there any long term safety data at all or is it phase 2 and hope 16:40
- chain_of_custody — lost 29kg over 4 months at doses well under what the trials used 17:59
- mg_per_ml — is TRIUMPH the phase 3 programme i log resting heart rate every morning because of this and its the one number i actually watch 20:09
why does everyone insist on smaller steps here than on the other two
stepping in 7.5 increments instead of doubling is the only thing i would change if i started again
smaller steps here
mine went up too
follow up no idea whether the heart rate settles for everyone, mine did and one log isnt data, still working it out
unrelated but back after 13 months, has anything actually been published since
no long term data
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)quick one is there any long term safety data at all or is it phase 2 and hope
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)⚠️3🧪13❤️15
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, someone check my working
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
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cant feel it honestly
did anyone come off because of the heart rate
anyone gone above 2 and what changed
TRIUMPH is phase 3
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
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sat at 2.5 for 2 months rather than climbing and it kept working, so i never went up
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low and slow
held mine ages
people insist on small steps because the side effects arrive faster than on the other two
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
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does the glucagon arm explain the heart rate or is that unrelated
came off at 28 weeks because my resting rate stayed elevated and i didnt like it
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phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
did the phase 2 plateau or was it still moving at the end
lost 29kg over 4 months at doses well under what the trials used
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im at 10 and the appetite effect is stronger than i expected, normal
[edited]anyone reconstituting 15 vials to 10 so the steps come out smaller
Recon calculator: 20mg in 1.5ml = 8mg/ml.
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the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
settled by month three
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
my resting rate went up 7 bpm in the first month and came back most of the way by month 3
the heart rate thing is real enough that i mention it whenever someone asks about starting
slightly off topic but TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
Digest for the week of 2025-12-25 has been published.
how slow is low and slow here, four weeks a step or longer
*week 13 not week 4
i log resting heart rate every morning because of this and its the one number i actually watch
*Medutest not the other one
Batch lookup G-0641: 2 independent reports on file, earliest 2026-02-10.
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anyone compared their VendorInvestigate purity across two different JEEP lots
reconstituted the 5 vial to 4mg/ml specifically so i could take 1 without measuring crumbs
how long before people saw the first change at 2.5
anyone tracking blood pressure alongside the heart rate
whats a sensible starting point, im seeing everything from 0.5 to 2
anyone stayed at 15 for months rather than climbing
whats the half life like, is it weekly the same way
my resting heart rate is up about 5 bpm, did that settle for anyone
follow up research use only is on every vial and i treat it as exactly that, nobody here is prescribing
watching my heart rate
is TRIUMPH the phase 3 programme
i log resting heart rate every morning because of this and its the one number i actually watch
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glucagon is the new bit
anyone logging resting heart rate on this
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
stopped for 12 months and restarted at half my old dose, the ramp was easier second time
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held at 0.25 for 3 months and it never plateaued for me, which i cant explain
the half life supports weekly dosing and thats what ive done from the start
the purity spread across lots worries me more than the molecule does, ask me again in a month
coa-c-4402.pdf
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