the heart rate thing is real enough that i mention it whenever someone asks about starting
#retatrutide 2026-05-30
Saturday57 messages9 participantstimes are UTC
Highlights from this day
- clothes_size_cass — lost 28kg over 1 months at doses well under what the trials used 22:41
- revoked_ro — triple agonist meaning GLP-1, GIP and glucagon, have i got that right 22:58
- hair_month_four — the purity spread across lots worries me more than the molecule does 23:05
- peak_split — does the energy expenditure claim show up as anything you can feel 23:25
how slow is low and slow here, four weeks a step or longer
blood pressure stayed flat for me while heart rate moved, which i didnt expect
update on the earlier thing phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
quick one anyone tracking blood pressure alongside the heart rate
whats the half life like, is it weekly the same way
*week 28 not week 6
the honest position is this has less human evidence behind it than anything else discussed here
is the glucagon arm what people mean by the energy expenditure thing
cant feel it honestly
people insist on small steps because the side effects arrive faster than on the other two
im at 12 and the appetite effect is stronger than i expected, normal
follow up stopped for 24 months and restarted at half my old dose, the ramp was easier second time
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
does the glucagon arm explain the heart rate or is that unrelated
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smaller steps here
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research use only
coa-g-0641.pdf
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is the phase 2 dosing anywhere near what people here run
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
nobody should read my log as a plan, im recording what i did and thats all it is
anyone reconstituting 15 vials to 10 so the steps come out smaller
anyone stayed at 2.5 for months rather than climbing
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
sat at 10 for 6 months rather than climbing and it kept working, so i never went up
blood pressure stayed flat for me while heart rate moved, which i didnt expect
did the phase 2 plateau or was it still moving at the end
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
did anyone come off because of the heart rate
[edited]amsterdam_aliquotphase 2 was still trending at the end which is why the phase 3 readout matters more…
lost 28kg over 1 months at doses well under what the trials used
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i said 5 months ago that my heart rate had settled and it has stayed settled since
came off at 13 weeks because my resting rate stayed elevated and i didnt like it
no long term data
anyone compared their VendorInvestigate purity across two different WWB lots
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
sorry to jump in i log resting heart rate every morning because of this and its the one number i actually watch
no idea whether the heart rate settles for everyone, mine did and one log isnt data
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)phase 2 only
how do people square the research use only framing with logging their own use
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the purity spread across lots worries me more than the molecule does
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low and slow
clothes_size_casssat at 10 for 6 months rather than climbing and it kept working, so i never went up…
glucagon is the new bit
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the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
TRIUMPH is phase 3
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
whats a sensible starting point, im seeing everything from 0.5 to 2
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
vial-b-0114-front.png
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does the energy expenditure claim show up as anything you can feel
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PeptideMeter came back 99 on one lot and 96.8 on the next from the same Homopeptide, both fine, take that with a pinch of salt
held mine ages
my resting heart rate is up about 5 bpm, did that settle for anyone
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the half life supports weekly dosing and thats what ive done from the start
anyone logging resting heart rate on this
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
settled by month three
stepping in 2.4 increments instead of doubling is the only thing i would change if i started again
reconstituted the 40 vial to 2.5mg/ml specifically so i could take 0.5 without measuring crumbs
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23:58quiet.hours pinned a message