low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
#retatrutide 2026-05-29
Friday42 messages8 participantstimes are UTC
Highlights from this day
- is_this_forever — buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely 16:23
- meal_prep_mick — the half life supports weekly dosing and thats what ive done from the start 17:58
- wrong_network — phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan 18:44
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
TRIUMPH is phase 3
lost 5kg over 14 months at doses well under what the trials used
*VendorInvestigate not the other one
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
is the phase 2 dosing anywhere near what people here run
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
👀1✅10🔥6
sat at 1 for 5 months rather than climbing and it kept working, so i never went up
back after 19 months, has anything actually been published since
i log resting heart rate every morning because of this and its the one number i actually watch
does the glucagon arm explain the heart rate or is that unrelated
anyone gone above 10 and what changed
my resting rate went up 8 bpm in the first month and came back most of the way by month 24
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point, n of 1 obviously
anyone tracking blood pressure alongside the heart rate
mine went up too
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
anyone logging resting heart rate on this
held at 1 for 4 months and it never plateaued for me, which i cant explain
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
sorry to jump in stopped for 23 months and restarted at half my old dose, the ramp was easier second time
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
no long term data
how long before people saw the first change at 1
❤️2
the heart rate thing is real enough that i mention it whenever someone asks about starting
follow up came off at 30 weeks because my resting rate stayed elevated and i didnt like it
settled by month three
anyone stayed at 0.5 for months rather than climbing
slightly off topic but energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
the half life supports weekly dosing and thats what ive done from the start
😂13💀1🙏1
research use only
logging rhr daily
slightly off topic but no idea whether the heart rate settles for everyone, mine did and one log isnt data, i think
stepping in 0.25 increments instead of doubling is the only thing i would change if i started again
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
🧪14👍9
my resting heart rate is up about 4 bpm, did that settle for anyone
anyone compared their PeptideMeter purity across two different TFC lots
held mine ages
📈7💀3
did the phase 2 result actually come in higher than the tirzepatide numbers
smaller steps here
Inter-lab diff for lot B-0114: 99.4% vs 99.2%. Within expected range.
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history