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#retatrutide 2026-06-03

Wednesday25 messages7 participantstimes are UTC
Highlights from this day
  • VialBot — Batch lookup A-2601: 7 independent reports on file, earliest 2026-03-11. 16:12
  • verify_or_dont — the heart rate thing is real enough that i mention it whenever someone asks about starting 17:39
  • VialBot — Inter-lab diff for lot C-4402: 99.2% vs 99%. Within expected range. 18:02
RS

my resting rate went up 9 bpm in the first month and came back most of the way by month 8

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is the phase 2 dosing anywhere near what people here run

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triple agonist meaning GLP-1, GIP and glucagon, have i got that right

VB

Batch lookup A-2601: 7 independent reports on file, earliest 2026-03-11.

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VO

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

settled by month three

TRIUMPH is phase 3

VV

how slow is low and slow here, four weeks a step or longer
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

anyone gone above 10 and what changed

VO

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

is TRIUMPH the phase 3 programme

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glucagon is the new bit

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the heart rate thing is real enough that i mention it whenever someone asks about starting

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VB

Inter-lab diff for lot C-4402: 99.2% vs 99%. Within expected range.

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ST

anyone tracking blood pressure alongside the heart rate

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
UU

slightly off topic but stepping in 0.25 increments instead of doubling is the only thing i would change if i started again

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.

no long term data

reconstituted the 2 vial to 10mg/ml specifically so i could take 5 without measuring crumbs

blood pressure stayed flat for me while heart rate moved, which i didnt expect, i could be wrong