anyone logging resting heart rate on this
#retatrutide 2026-06-04
Thursday54 messages12 participantstimes are UTC
Highlights from this day
- lean_mass_lex — does the energy expenditure claim show up as anything you can feel 20:23
- two_labs_two_answers — the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me 20:53
- zoya_zeros — ok so GI was about the same as tirzepatide for me, the difference was how fast it arrived 21:31
- lean_mass_lex — buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely 23:11
does the energy expenditure claim show up as anything you can feel
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low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, i think
is TRIUMPH the phase 3 programme
did the phase 2 result actually come in higher than the tirzepatide numbers
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
*VendorInvestigate not the other one
my resting rate went up 7 bpm in the first month and came back most of the way by month 12
logging rhr daily
[edited]i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
Janoshik came back 98.1 on one lot and 99.2 on the next from the same HJ, both fine
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
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energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
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people insist on small steps because the side effects arrive faster than on the other two
triple agonist yeah
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phase 2 only
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research use only
my resting heart rate is up about 5 bpm, did that settle for anyone
anyone compared their VendorInvestigate purity across two different GL Biochem lots
watching my heart rate
smaller steps here
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nobody should read my log as a plan, im recording what i did and thats all it is
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, from memory
no idea whether the heart rate settles for everyone, mine did and one log isnt data
low and slow
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
ok so GI was about the same as tirzepatide for me, the difference was how fast it arrived
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came off at 19 weeks because my resting rate stayed elevated and i didnt like it
anyone reconstituting 10 vials to 10 so the steps come out smaller
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
whats the half life like, is it weekly the same way
the honest position is this has less human evidence behind it than anything else discussed here
On this day 3 years ago this channel logged 78 messages.
anyone stayed at 15 for months rather than climbing
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phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
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mine went up too
coming back to this phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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triple agonist meaning GLP-1, GIP and glucagon, have i got that right
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while im here held at 0.25 for 16 months and it never plateaued for me, which i cant explain
Reminder set. I will post here in 8 days.
blood pressure stayed flat for me while heart rate moved, which i didnt expect
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
back after 1 months, has anything actually been published since
is the glucagon arm what people mean by the energy expenditure thing
the purity spread across lots worries me more than the molecule does
sorry to jump in did the phase 2 plateau or was it still moving at the end
[edited]i log resting heart rate every morning because of this and its the one number i actually watch
blood pressure stayed flat for me while heart rate moved, which i didnt expect
whats a sensible starting point, im seeing everything from 0.5 to 2
coming back to this cant feel it honestly
glucagon is the new bit
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
lost 48kg over 7 months at doses well under what the trials used
no long term data
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
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held mine ages