stepping in 0.25 increments instead of doubling is the only thing i would change if i started again, i could be wrong
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#retatrutide 2026-06-05
Friday45 messages9 participantstimes are UTC
Highlights from this day
- power_through_no — the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, ask me again in a month 20:57
- void_volume — did anyone come off because of the heart rate 21:29
- adelaide_assay — anyone tracking blood pressure alongside the heart rate 21:34
- hair_month_four — low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom 23:19
low and slow
came off at 27 weeks because my resting rate stayed elevated and i didnt like it
cant feel it honestly
whats a sensible starting point, im seeing everything from 0.5 to 2
glucagon is the new bit
the half life supports weekly dosing and thats what ive done from the start
[edited]the honest position is this has less human evidence behind it than anything else discussed here
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
coming back to this people insist on small steps because the side effects arrive faster than on the other two
no long term data
transit-times.csv
340 rows · not retained in the public archive
blood pressure stayed flat for me while heart rate moved, which i didnt expect
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, happy to be corrected
back after 4 months, has anything actually been published since
smaller steps here
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, ask me again in a month
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research use only
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
reconstituted the 5 vial to 2.5mg/ml specifically so i could take 1.7 without measuring crumbs
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, happy to be corrected
logging rhr daily
nobody should read my log as a plan, im recording what i did and thats all it is
did anyone come off because of the heart rate
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research use only is on every vial and i treat it as exactly that, nobody here is prescribing, take that with a pinch of salt
watching my heart rate
anyone tracking blood pressure alongside the heart rate
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settled by month three
mine went up too
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TRIUMPH is phase 3
Janoshik came back 98.6 on one lot and 97.4 on the next from the same GL Biochem, both fine
GI was about the same as tirzepatide for me, the difference was how fast it arrived
the purity spread across lots worries me more than the molecule does
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
is the phase 2 dosing anywhere near what people here run
the heart rate thing is real enough that i mention it whenever someone asks about starting
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anyone reconstituting 30 vials to 2.5 so the steps come out smaller
*PeptideMeter not the other one
does the energy expenditure claim show up as anything you can feel
phase 2 only
unrelated but phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
triple agonist yeah
i log resting heart rate every morning because of this and its the one number i actually watch
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
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