research use only
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#retatrutide 2026-06-22
Monday35 messages10 participantstimes are UTC
Highlights from this day
- cold_chain_cmdr — unrelated but i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind 20:41
- still_here_2024 — the honest position is this has less human evidence behind it than anything else discussed here, someone check my working 20:52
- coelution_cai — people insist on small steps because the side effects arrive faster than on the other two 21:26
- pbs_pip — update on the earlier thing no idea whether the heart rate settles for everyone, mine did and one log isnt data 22:26
- dana_titrates — how slow is low and slow here, four weeks a step or longer 22:27
unrelated but i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
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i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps, i think
the honest position is this has less human evidence behind it than anything else discussed here, someone check my working
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
does the energy expenditure claim show up as anything you can feel
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, n of 1 obviously
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did the phase 2 result actually come in higher than the tirzepatide numbers
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i log resting heart rate every morning because of this and its the one number i actually watch
held at 5 for 8 months and it never plateaued for me, which i cant explain
im at 1 and the appetite effect is stronger than i expected, normal
people insist on small steps because the side effects arrive faster than on the other two
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nobody should read my log as a plan, im recording what i did and thats all it is
did the phase 2 plateau or was it still moving at the end
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cant feel it honestly
GI was about the same as tirzepatide for me, the difference was how fast it arrived
nobody should read my log as a plan, im recording what i did and thats all it is
mine went up too
did anyone come off because of the heart rate
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lost 10kg over 23 months at doses well under what the trials used
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
sat at 0.5 for 2 months rather than climbing and it kept working, so i never went up
watching my heart rate
glucagon is the new bit
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anyone logging resting heart rate on this
smaller steps here
stepping in 2.4 increments instead of doubling is the only thing i would change if i started again
slightly off topic but stopped for 16 months and restarted at half my old dose, the ramp was easier second time
triple agonist yeah
update on the earlier thing no idea whether the heart rate settles for everyone, mine did and one log isnt data
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how slow is low and slow here, four weeks a step or longer
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triple agonist meaning GLP-1, GIP and glucagon, have i got that right
how long before people saw the first change at 0.25
slightly off topic but triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
settled by month three