phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
#retatrutide 2026-06-21
Sunday58 messages12 participantstimes are UTC
Highlights from this day
- evidence_or_not — did the phase 2 plateau or was it still moving at the end lost 28kg over 11 months at doses well under what the trials used 19:53
- quiet.hours — while im here the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me 19:59
- zoya_zeros — i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind reconstituted the 15 vial to 2.5mg/ml specifically so i could… 20:28
- acetate_ash — sat at 2.5 for 7 months rather than climbing and it kept working, so i never went up, i could be wrong 22:21
- acetate_ash — the purity spread across lots worries me more than the molecule does, ask me again in a month 23:21
does the glucagon arm explain the heart rate or is that unrelated
unrelated but is TRIUMPH the phase 3 programme
did the phase 2 plateau or was it still moving at the end
lost 28kg over 11 months at doses well under what the trials used
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lost 45kg over 24 months at doses well under what the trials used
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the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, n of 1 obviously
while im here the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
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triple agonist yeah
Reminder for quiet.hours: dose day is today. Set 7 days ago.
Inter-lab diff for lot D-0718: 98.6% vs 96.8%. Within expected range.
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held at 1.7 for 5 months and it never plateaued for me, which i cant explain
no long term data
anyone compared their VendorInvestigate purity across two different SWB lots
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
Inter-lab diff for lot SG-1177: 98.6% vs 96.8%. Within expected range.
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anyone gone above 10 and what changed
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)while im here people insist on small steps because the side effects arrive faster than on the other two
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
reconstituted the 15 vial to 2.5mg/ml specifically so i could take 7.5 without measuring crumbs
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mine went up too
Archive lookup: mg_per_ml first appears in this channel on 2025-12-30.
Archive lookup: mg_per_ml first appears in this channel on 2025-10-23.
stepping in 7.5 increments instead of doubling is the only thing i would change if i started again
watching my heart rate
i said 6 months ago that my heart rate had settled and it has stayed settled since, someone check my working
nobody should read my log as a plan, im recording what i did and thats all it is
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
VendorInvestigate came back 99.4 on one lot and 98.6 on the next from the same CPC, both fine
sorry to jump in anyone reconstituting 10 vials to 2 so the steps come out smaller
how slow is low and slow here, four weeks a step or longer
how long before people saw the first change at 1.7
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im at 7.5 and the appetite effect is stronger than i expected, normal
logging rhr daily
i log resting heart rate every morning because of this and its the one number i actually watch
vial-d-0718-front.png
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21:06quiet.hours pinned a message
Inter-lab diff for lot F-1330: 99.4% vs 97.4%. Within expected range.
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
anyone tracking blood pressure alongside the heart rate
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energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
phase 2 only
TRIUMPH is phase 3
back after 10 months, has anything actually been published since
is the GI worse than tirzepatide or about the same
the heart rate thing is real enough that i mention it whenever someone asks about starting
did anyone come off because of the heart rate
my resting rate went up 8 bpm in the first month and came back most of the way by month 23
cant feel it honestly
settled by month three
appetite suppression at 12 was stronger than my tirzepatide experience at a comparable point
sat at 2.5 for 7 months rather than climbing and it kept working, so i never went up, i could be wrong
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*Janoshik not the other one
low and slow
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for the archive triple agonist meaning GLP-1, GIP and glucagon, have i got that right
research use only
smaller steps here
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
the purity spread across lots worries me more than the molecule does, ask me again in a month
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