vialroom

#semaglutide 2024-03-09

Saturday20 messages4 participantstimes are UTC
Highlights from this day
  • retention_time — did anybody find a difference between QYB and pharmacy at the same 1.7 16:49
  • sharps_bin_sid — genuine question im at 0.5 and stuck, did anyone break a plateau without going up 17:55
  • sharps_bin_sid — how did people handle the jump from 1 to 1.7 19:12
PF

update on the earlier thing how many weeks before you noticed anything at 2.5

my 15 vial in 1ml gives 4mg/ml so 1.7 lands on 8 units, thats why i picked that volume

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

RT

did anybody find a difference between QYB and pharmacy at the same 1.7

👍18
RT

update on the earlier thing did anyone titrate slower than four weeks a step and how did that go

*that should say weekly

PF

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step

TE

26 months at 2.4 and the honest summary is diminishing returns after the first half

thats STEP 1

five week steps worked better for me than four, purely on how the second week felt, take that with a pinch of salt
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

SB

STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, happy to be corrected

genuine question im at 0.5 and stuck, did anyone break a plateau without going up

👀3💀18

how long till steady state, ive read the half life is about a week

SB

is 2.4 the top or do people go past it

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.

how did people handle the jump from 1 to 1.7

💀4🔥10

i stayed on 1.7 for 1 months and never went to 2.4, appetite was already where i needed it

SB

the plateau hit me at 4 weeks and moved again about a month later without a dose change