while im here i dont think the plateau is a dose problem most of the time, but i cant prove that
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#semaglutide 2024-07-24
Wednesday36 messages8 participantstimes are UTC
Highlights from this day
- area_percent — while im here i dont think the plateau is a dose problem most of the time, but i cant prove that 17:26
- a1c_lag — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, anyway 18:24
- mg_per_ml — did anyone titrate slower than four weeks a step and how did that go 19:18
- abdo_two_inch — unrelated but my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 19:37
- area_percent — my Janoshik report on the KP vial came back 99.4 against a certificate saying 97.4 20:14
is the plateau at 20 weeks normal or am i doing something wrong
seven days ish
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went too fast once
plateaus move
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the appetite effect faded for me around 22 months and going up fixed it for a while
half life is about a week so youre roughly four to five weeks to steady state on any new dose
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
vial units and pen clicks are different systems, mixing the two is how people end up wrong
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, anyway
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dose day is sunday for me only because thats when i remember, not because sunday matters, someone check my working
my 5 vial in 1.5ml gives 2mg/ml so 1.7 lands on 20 units, thats why i picked that volume
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
i held at 0.5 for 8 months and it was the best decision i made
while im here SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
genuine question did anyone hold at 2.4 longer than four weeks before going up
held there too
give it four weeks
did anyone titrate slower than four weeks a step and how did that go
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
18 months at 2.4 and the honest summary is diminishing returns after the first half
compounded and brand felt the same to me at 2.4, which is one person and nothing more
my dose day drifted from friday to sunday, does that reset anything
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
unrelated but my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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i stayed on 1.7 for 18 months and never went to 2.4, appetite was already where i needed it
thats STEP 1
SELECT wasnt weight
my Janoshik report on the KP vial came back 99.4 against a certificate saying 97.4
[edited]does moving my dose day by two days matter with a seven day half life
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
[edited]how did people handle the jump from 1 to 1.7
dose day is sunday for me only because thats when i remember, not because sunday matters
not the same trial
same dose day
five week steps worked better for me than four, purely on how the second week felt, happy to be corrected
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the plateau hit me at 3 weeks and moved again about a month later without a dose change
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
slower worked better
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