#semaglutide 2024-07-27

Saturday22 messages6 participantstimes are UTC

Highlights from this day

HPLC_Hank — was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up 11:01
HPLC_Hank — i held at 12 for 2 months and it was the best decision i made 11:32
plateau_pen — genuine question i stayed on 1.7 for 25 months and never went to 2.4, appetite was already where i needed it 12:48
plateau_pen — dose day is sunday for me only because thats when i remember, not because sunday matters 12:49
mg_per_ml — anyone compared their 2.5 vial dosing against the pen increments 13:07

was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

i held at 12 for 2 months and it was the best decision i made

💀12🧊7✅4

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

coming back to this what did SELECT actually measure, i see it quoted for everything

the plateau hit me at 9 weeks and moved again about a month later without a dose change

does the seven day half life mean the last two days are weaker

how long till steady state, ive read the half life is about a week

unrelated but did the STEP 4 withdrawal arm show what i think it showed

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

not the same trial

while im here how many weeks before you noticed anything at 15

held at 2.5 and lost 75lb over 18 months, slower than the trials and fine by me

is the plateau usually appetite coming back or just the scale stopping

genuine question i stayed on 1.7 for 25 months and never went to 2.4, appetite was already where i needed it

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

😂1📉6

dose day is sunday for me only because thats when i remember, not because sunday matters

my dose day drifted from friday to sunday, does that reset anything

✅1

is there a reason to hold at 1.7 rather than going to 2.4

i dont think the plateau is a dose problem most of the time, but i cant prove that, thats just me

SELECT wasnt weight

held there too

anyone compared their 2.5 vial dosing against the pen increments

✅9

slightly off topic but five week steps worked better for me than four, purely on how the second week felt

[edited]

🔥1🤝1