anyone compared their 2.5 vial dosing against the pen increments
#semaglutide 2024-08-25
Sunday30 messages8 participantstimes are UTC
Highlights from this day
- pinch_not_stretch — ok so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 18:49
- surpass_two — update on the earlier thing the plateau hit me at 23 weeks and moved again about a month later without a dose change 19:05
- split_dose_sam — i stayed on 1.7 for 13 months and never went to 2.4, appetite was already where i needed it 20:09
- half_life_hal — i dont think the plateau is a dose problem most of the time, but i cant prove that 20:45
- surpass_two — my Medutest report on the QST vial came back 99.2 against a certificate saying 99.4 21:15
same dose day
steady state takes weeks
weights-monthly.csv
146 rows · not retained in the public archive
STEP is several trials, so saying STEP said x is usually wrong without a number after it, i could be wrong
does the seven day half life mean the last two days are weaker
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
went too fast once
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
right so dose day is sunday for me only because thats when i remember, not because sunday matters
SELECT wasnt weight
Inter-lab diff for lot G-0641: 96.8% vs 99.2%. Within expected range.
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ok so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg📉6
compounded and brand felt the same to me at 2.4, which is one person and nothing more
update on the earlier thing the plateau hit me at 23 weeks and moved again about a month later without a dose change
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
❤️3👀12🔥4
the appetite effect faded for me around 15 months and going up fixed it for a while
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
vials not pens here
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2.4 is the ceiling
held there too
i stayed on 1.7 for 13 months and never went to 2.4, appetite was already where i needed it
📉1✅14🔥4
half life is about a week so youre roughly four to five weeks to steady state on any new dose
how did people handle the jump from 1 to 1.7
i dont think the plateau is a dose problem most of the time, but i cant prove that
👍6💀4🎉14
12 months at 2.4 and the honest summary is diminishing returns after the first half
update on the earlier thing €55 a month for compounded against what brand costs locally is why most people here use vials
unrelated but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, thats one data point
my Medutest report on the QST vial came back 99.2 against a certificate saying 99.4
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgi held at 10 for 8 months and it was the best decision i made
my 10 vial in 2ml gives 2.5mg/ml so 2 lands on 30 units, thats why i picked that volume
whats the actual licensed ceiling, i keep seeing different numbers