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#semaglutide 2024-08-26

Monday34 messages8 participantstimes are UTC
Highlights from this day
  • five_mg_ml — did anyone titrate slower than four weeks a step and how did that go 16:37
  • night_pin — moving my dose day by a day or two never did anything noticeable for me 18:23
  • night_pin — restarted after 12 months off at a low dose and the nausea arrived exactly like the first time 18:25
  • VialBot — Archive lookup: night_pin first appears in this channel on 2024-05-30. 18:46

2 months at 2.4 and the honest summary is diminishing returns after the first half

TE

im at 1 and stuck, did anyone break a plateau without going up
i dont think the plateau is a dose problem most of the time, but i cant prove that

🙏1

how did people handle the jump from 1 to 1.7

TE

held at 10 and lost 87lb over 19 months, slower than the trials and fine by me

⚠️2
SD

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

seven days ish

FM

did anyone titrate slower than four weeks a step and how did that go

Cited study
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
New England Journal of Medicine · 2021
68 weeks, semaglutide 2.4mg weekly against placebo, with lifestyle intervention in both arms.

went too fast once

VB

Reminder for lyophile_liv: dose day is today. Set 8 days ago.

TF

quick one my dose day drifted from friday to sunday, does that reset anything

quick one i held at 1.7 for 4 months and it was the best decision i made

TF

was FLOW the one that ran to 68 weeks or am i mixing them up

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

RR

half life is about a week so youre roughly four to five weeks to steady state on any new dose

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

RR

lost about 4kg on the low doses before i even got to 1, which surprised me, someone check my working

NP

moving my dose day by a day or two never did anything noticeable for me

🔥1013❤️5

restarted after 12 months off at a low dose and the nausea arrived exactly like the first time

👀12
VB

Archive lookup: night_pin first appears in this channel on 2024-05-30.

RR

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, anyway

❤️1🔥1

did the STEP 4 withdrawal arm show what i think it showed

RR

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

slower worked better

VB

Inter-lab diff for lot H-2814: 98.1% vs 97.4%. Within expected range.

TE

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication