restarted after 22 months off at a low dose and the nausea arrived exactly like the first time
#semaglutide 2024-08-27
Tuesday43 messages11 participantstimes are UTC
Highlights from this day
- first_and_last_four — does anyone actually run a five week step instead of four 21:58
- food_noise_off — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 22:36
- food_noise_off — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 22:59
- customs_owl — anyone gone from 2 straight to 2.5 or is that too big a jump 23:04
steady state takes weeks
2.4 is the ceiling
went too fast once
does anyone actually run a five week step instead of four
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
give it four weeks
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follow up held at 7.5 and lost 99lb over 21 months, slower than the trials and fine by me
23 months at 2.4 and the honest summary is diminishing returns after the first half
STEP is several trials, so saying STEP said x is usually wrong without a number after it, i think
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
vial units and pen clicks are different systems, mixing the two is how people end up wrong
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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vials not pens here
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does the seven day half life mean the last two days are weaker
plateaus move
[edited]SELECT wasnt weight
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was STEP 1 the one that ran to 68 weeks or am i mixing them up
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
lost about 16kg on the low doses before i even got to 1, which surprised me
not the same trial
sorry to jump in going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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what did SELECT actually measure, i see it quoted for everything
how did people handle the jump from 1 to 1.7
the long half life flattens the trough more than people expect, i never felt a day seven dip, we shall see
does moving my dose day by two days matter with a seven day half life
held at 2.4 and lost 80lb over 8 months, slower than the trials and fine by me
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for the archive how long till steady state, ive read the half life is about a week
did anyone titrate slower than four weeks a step and how did that go
STEP 1 ran to 68 weeks. thats the one everyone half remembers, thats just me
im 7 months in at 12 and the appetite effect faded, is that a thing
[edited]the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg✅1
the appetite effect faded for me around 19 months and going up fixed it for a while, we shall see
slightly off topic but 22 months at 2.4 and the honest summary is diminishing returns after the first half
anyone gone from 2 straight to 2.5 or is that too big a jump
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i held at 10 for 5 months and it was the best decision i made
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Assay note: WXT lot SG-1177 reported at 98.6% of label content.
im at 0.25 and stuck, did anyone break a plateau without going up
my 5 vial in 2ml gives 4mg/ml so 1 lands on 8 units, thats why i picked that volume, ill dig out the number
i dont think the plateau is a dose problem most of the time, but i cant prove that
ok so dose day is sunday for me only because thats when i remember, not because sunday matters
first_and_last_fourthe long half life flattens the trough more than people expect, i never felt a day…
for the archive how long did the first 48kg take for people at the low doses