sorry to jump in went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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#semaglutide 2024-12-06
Friday23 messages5 participantstimes are UTC
Highlights from this day
- non_scale_win — sorry to jump in went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 18:19
- non_scale_win — the long half life flattens the trough more than people expect, i never felt a day seven dip, thats one data point 18:39
- quiet.hours — is the plateau usually appetite coming back or just the scale stopping 19:00
- first_and_last_four — STEP is several trials, so saying STEP said x is usually wrong without a number after it, your mileage will differ 19:05
- first_and_last_four — did anyone hold at 15 longer than four weeks before going up 22:03
lost about 28kg on the low doses before i even got to 1, which surprised me
the long half life flattens the trough more than people expect, i never felt a day seven dip, thats one data point
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
thats STEP 1
the appetite effect faded for me around 10 months and going up fixed it for a while, take that with a pinch of salt
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my dose day drifted from friday to sunday, does that reset anything
coming back to this how long did the first 33kg take for people at the low doses
is the plateau usually appetite coming back or just the scale stopping
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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right so im 7 months in at 1.7 and the appetite effect faded, is that a thing
plateaus move
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSTEP is several trials, so saying STEP said x is usually wrong without a number after it, your mileage will differ
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did the STEP 4 withdrawal arm show what i think it showed
STEP 1 ran to 68 weeks. thats the one everyone half remembers
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
anyone compared their 2.5 vial dosing against the pen increments
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
im at 2.4 and stuck, did anyone break a plateau without going up
[edited]how long till steady state, ive read the half life is about a week
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
2.4 is the ceiling
[edited]vials not pens here
for the archive whats the actual licensed ceiling, i keep seeing different numbers
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, your mileage will differ
did anyone hold at 15 longer than four weeks before going up
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