SELECT wasnt weight
#semaglutide 2025-02-09
Sunday35 messages7 participantstimes are UTC
Highlights from this day
- half_life_hal — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 15:20
- stack_sceptic — STEP 1 ran to 68 weeks. thats the one everyone half remembers went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step 15:46
- half_life_hal — coming back to this restarted after 24 months off at a low dose and the nausea arrived exactly like the first time, still working it out 16:45
- vienna_vial — unrelated but i held at 0.5 for 3 months and it was the best decision i made 18:59
the long half life flattens the trough more than people expect, i never felt a day seven dip
is 2.4 the top or do people go past it
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
🧪10
how long did the first 10kg take for people at the low doses
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
plateaus move
STEP 1 ran to 68 weeks. thats the one everyone half remembers
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
not the same trial
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brand vs compounded, is there a difference people can actually feel
anyone gone from 12 straight to 1 or is that too big a jump
five week steps worked better for me than four, purely on how the second week felt
while im here vial units and pen clicks are different systems, mixing the two is how people end up wrong
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
i held at 0.5 for 8 months and it was the best decision i made
whats the actual licensed ceiling, i keep seeing different numbers
was SELECT the one that ran to 68 weeks or am i mixing them up
coming back to this restarted after 24 months off at a low dose and the nausea arrived exactly like the first time, still working it out
is the plateau at 5 weeks normal or am i doing something wrong
how long till steady state, ive read the half life is about a week
slower worked better
🤝3✅2🙏8
held there too
📈9
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
1 months at 2.4 and the honest summary is diminishing returns after the first half
unrelated but i held at 0.5 for 3 months and it was the best decision i made
🤝7👍14🔥10
same dose day
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19:36tenpence pinned a message
does anyone actually run a five week step instead of four
my Janoshik report on the SWB vial came back 99.2 against a certificate saying 98.6
*VendorInvestigate not the other one
compounded and brand felt the same to me at 10, which is one person and nothing more
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
did anyone titrate slower than four weeks a step and how did that go