vials not pens here
#semaglutide 2025-02-25
Tuesday34 messages8 participantstimes are UTC
Highlights from this day
- two_four_ceiling — i stayed on 1.7 for 22 months and never went to 2.4, appetite was already where i needed it 15:13
- forty_units — STEP is several trials, so saying STEP said x is usually wrong without a number after it 15:22
- forty_units — restarted after 6 months off at a low dose and the nausea arrived exactly like the first time 15:59
- egfr_ed — is 2.4 the top or do people go past it 16:06
- two_eight_c — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 16:30
is there a reason to hold at 1.7 rather than going to 2.4
held at 12 and lost 77lb over 9 months, slower than the trials and fine by me
dose day is sunday for me only because thats when i remember, not because sunday matters
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
[edited]lost about 17kg on the low doses before i even got to 1, which surprised me
anyone compared their 2 vial dosing against the pen increments
went too fast once
i dont think the plateau is a dose problem most of the time, but i cant prove that
✅6
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
✅1🎉4
i stayed on 1.7 for 22 months and never went to 2.4, appetite was already where i needed it
📉5👀10
while im here does moving my dose day by two days matter with a seven day half life
anyone gone from 12 straight to 2.5 or is that too big a jump
STEP is several trials, so saying STEP said x is usually wrong without a number after it
⚠️9
unrelated but vial units and pen clicks are different systems, mixing the two is how people end up wrong
Inter-lab diff for lot B-0329: 99% vs 98.1%. Within expected range.
2.4 is the ceiling
thats STEP 1
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
✅3
restarted after 6 months off at a low dose and the nausea arrived exactly like the first time
❤️3🧊10
what did SELECT actually measure, i see it quoted for everything
slower worked better
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
steady state takes weeks
is 2.4 the top or do people go past it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
💀12❤️1
moving my dose day by a day or two never did anything noticeable for me
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
moving my dose day by a day or two never did anything noticeable for me
same dose day
[edited]back after 10 months off, do i restart at 0.25 or somewhere higher
is the plateau at 24 weeks normal or am i doing something wrong
*week 3 not week 2
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure