five week steps worked better for me than four, purely on how the second week felt, take that with a pinch of salt
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#semaglutide 2025-04-29
Tuesday43 messages8 participantstimes are UTC
Highlights from this day
- provincial_pat — five week steps worked better for me than four, purely on how the second week felt, take that with a pinch of salt 20:58
- verify_or_dont — how many weeks before you noticed anything at 2 22:01
- verify_or_dont — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 22:14
- two_three_lifts — whats the actual licensed ceiling, i keep seeing different numbers 22:37
- two_three_lifts — how long did the first 34kg take for people at the low doses 23:56
not the same trial
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
is 2.4 the top or do people go past it
genuine question i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
my dose day drifted from friday to sunday, does that reset anything
STEP 1 ran to 68 weeks. thats the one everyone half remembers, thats one data point
*PeptideMeter not the other one
held there too
*PeptideMeter not the other one
what did SELECT actually measure, i see it quoted for everything
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my 40 vial in 2ml gives 10mg/ml so 12 lands on 25 units, thats why i picked that volume, anyway
*mg/ml, obviously
im at 0.25 and stuck, did anyone break a plateau without going up
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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give it four weeks
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the long half life flattens the trough more than people expect, i never felt a day seven dip
coa-sg-1177.pdf
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€120 a month for compounded against what brand costs locally is why most people here use vials, for what its worth
anyone compared their 4 vial dosing against the pen increments
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it, still working it out
how many weeks before you noticed anything at 2
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steady state takes weeks
how long till steady state, ive read the half life is about a week
moving my dose day by a day or two never did anything noticeable for me
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg📈4😂1✅12
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
my Janoshik report on the QSC vial came back 99.4 against a certificate saying 99.2
how did people handle the jump from 1 to 1.7
slower worked better
i held at 2.5 for 4 months and it was the best decision i made
whats the actual licensed ceiling, i keep seeing different numbers
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgvials not pens here
12 months at 2.4 and the honest summary is diminishing returns after the first half
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, i think
the appetite effect faded for me around 18 months and going up fixed it for a while
mine faded too
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
held at 1.7 and lost 47lb over 26 months, slower than the trials and fine by me
back after 20 months off, do i restart at 0.25 or somewhere higher
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
how long did the first 34kg take for people at the low doses
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