was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
#semaglutide 2025-04-30
Wednesday47 messages10 participantstimes are UTC
Highlights from this day
- monoisotopic — went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step 18:23
- monoisotopic — i stayed on 1.7 for 20 months and never went to 2.4, appetite was already where i needed it 18:45
- salt_bridge — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 18:55
- apnoea_down_two — the long half life flattens the trough more than people expect, i never felt a day seven dip 19:37
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, for what its worth
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five week steps worked better for me than four, purely on how the second week felt
STEP 1 ran to 68 weeks. thats the one everyone half remembers
steady state takes weeks
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thats STEP 1
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i stayed on 1.7 for 20 months and never went to 2.4, appetite was already where i needed it
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgdid anyone titrate slower than four weeks a step and how did that go
not the same trial
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
held there too
11 months at 2.4 and the honest summary is diminishing returns after the first half
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$94 a month for compounded against what brand costs locally is why most people here use vials
did anybody find a difference between JEEP and pharmacy at the same 12
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
my 40 vial in 2.5ml gives 2mg/ml so 1.7 lands on 8 units, thats why i picked that volume
*mg/ml, obviously
the appetite effect faded for me around 17 months and going up fixed it for a while
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
the long half life flattens the trough more than people expect, i never felt a day seven dip
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moving my dose day by a day or two never did anything noticeable for me, still working it out
lost about 21kg on the low doses before i even got to 1, which surprised me, your mileage will differ
back after 23 months off, do i restart at 0.25 or somewhere higher
restarted after 15 months off at a low dose and the nausea arrived exactly like the first time
for the archive anyone compared their 5 vial dosing against the pen increments
give it four weeks
plateaus move
my dose day drifted from friday to sunday, does that reset anything
[edited]does anyone actually run a five week step instead of four
slower worked better
how many weeks before you noticed anything at 2
anyone gone from 2.5 straight to 0.5 or is that too big a jump
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
the plateau hit me at 16 weeks and moved again about a month later without a dose change
SELECT wasnt weight
seven days ish
mine faded too
i held at 5 for 2 months and it was the best decision i made
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
[edited]is there a reason to hold at 1.7 rather than going to 2.4
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how long till steady state, ive read the half life is about a week
dose day is sunday for me only because thats when i remember, not because sunday matters, happy to be corrected
did anyone hold at 7.5 longer than four weeks before going up
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
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