not the same trial
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#semaglutide 2025-05-05
Monday52 messages12 participantstimes are UTC
Highlights from this day
- thank_you_year_on — how did people handle the jump from 1 to 1.7 16:49
- private_script_pri — lost about 32kg on the low doses before i even got to 1, which surprised me 17:28
- private_script_pri — while im here went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step 17:31
- bea_reconstitutes — quick one restarted after 24 months off at a low dose and the nausea arrived exactly like the first time, your mileage will differ 18:37
ok so FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
SELECT wasnt weight
five week steps worked better for me than four, purely on how the second week felt
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, ask me again in a month
while im here i dont think the plateau is a dose problem most of the time, but i cant prove that
while im here steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, from memory
[edited]seven days ish
how did people handle the jump from 1 to 1.7
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steady state takes weeks
Inter-lab diff for lot C-4402: 99% vs 99.4%. Within expected range.
sorry to jump in does moving my dose day by two days matter with a seven day half life
was STEP 4 the one that ran to 68 weeks or am i mixing them up
lost about 32kg on the low doses before i even got to 1, which surprised me
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
while im here went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
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anyone gone from 12 straight to 1 or is that too big a jump
*that should say weekly
same dose day
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update on the earlier thing went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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slower worked better
did anyone titrate slower than four weeks a step and how did that go
sorry to jump in if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
Batch lookup C-4402: 2 independent reports on file, earliest 2025-01-24.
sorry to jump in half life is about a week so youre roughly four to five weeks to steady state on any new dose
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held at 15 and lost 77lb over 11 months, slower than the trials and fine by me
vials not pens here
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
mine faded too
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plateaus move
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give it four weeks
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quick one restarted after 24 months off at a low dose and the nausea arrived exactly like the first time, your mileage will differ
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is the plateau usually appetite coming back or just the scale stopping
my dose day drifted from friday to sunday, does that reset anything
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, thats just me
ok so dose day is sunday for me only because thats when i remember, not because sunday matters
how long till steady state, ive read the half life is about a week
compounded and brand felt the same to me at 1.7, which is one person and nothing more
right so the long half life flattens the trough more than people expect, i never felt a day seven dip
back after 16 months off, do i restart at 0.25 or somewhere higher
genuine question is there a reason to hold at 1.7 rather than going to 2.4
right so how long did the first 26kg take for people at the low doses
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£94 a month for compounded against what brand costs locally is why most people here use vials
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
17 months at 2.4 and the honest summary is diminishing returns after the first half, thats one data point
[edited]thats STEP 1
held there too
does anyone actually run a five week step instead of four
[edited]my 5 vial in 5ml gives 2.5mg/ml so 2 lands on 12 units, thats why i picked that volume
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
[edited]im at 2.4 and stuck, did anyone break a plateau without going up
ok so my Medutest report on the WWB vial came back 98.6 against a certificate saying 99.2
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