the plateau hit me at 24 weeks and moved again about a month later without a dose change, not advice obviously
#semaglutide 2025-06-05
Thursday50 messages9 participantstimes are UTC
Highlights from this day
- hiccup_hollis — i dont think the plateau is a dose problem most of the time, but i cant prove that 18:42
- clothes_size_cass — vial units and pen clicks are different systems, mixing the two is how people end up wrong 18:44
- clothes_size_cass — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, we shall see 19:38
is there a reason to hold at 1.7 rather than going to 2.4
vials not pens here
is the plateau usually appetite coming back or just the scale stopping
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the long half life flattens the trough more than people expect, i never felt a day seven dip
Inter-lab diff for lot B-0329: 97.4% vs 99%. Within expected range.
not the same trial
right so is 2.4 the top or do people go past it
2.4 is the ceiling
[edited]mine faded too
slightly off topic but does the licensed ceiling for weight differ from the diabetes one
dose day is sunday for me only because thats when i remember, not because sunday matters
anyone gone from 10 straight to 5 or is that too big a jump
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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endotoxin_edslightly off topic but does the licensed ceiling for weight differ from the diabetes one
i dont think the plateau is a dose problem most of the time, but i cant prove that
vial units and pen clicks are different systems, mixing the two is how people end up wrong
janoshik-b-0329.pdf
2 pages · 254 KB · not retained in the public archive
back after 9 months off, do i restart at 0.25 or somewhere higher
steady state takes weeks
seven days ish
ok so does anyone actually run a five week step instead of four
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
slower worked better
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held there too
SELECT wasnt weight
im 23 months in at 2.4 and the appetite effect faded, is that a thing
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, we shall see
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did anyone hold at 12 longer than four weeks before going up
same dose day
plateaus move
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the appetite effect faded for me around 10 months and going up fixed it for a while
compounded and brand felt the same to me at 0.5, which is one person and nothing more
15 months at 2.4 and the honest summary is diminishing returns after the first half
[edited]ok so held at 1.7 and lost 37lb over 14 months, slower than the trials and fine by me
follow up what did SELECT actually measure, i see it quoted for everything
how many weeks before you noticed anything at 1
restarted after 6 months off at a low dose and the nausea arrived exactly like the first time
moving my dose day by a day or two never did anything noticeable for me
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
my Janoshik report on the BCH vial came back 98.1 against a certificate saying 96.8
half life is about a week so youre roughly four to five weeks to steady state on any new dose
does the seven day half life mean the last two days are weaker
five week steps worked better for me than four, purely on how the second week felt
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
€38 a month for compounded against what brand costs locally is why most people here use vials
went too fast once
i stayed on 1.7 for 1 months and never went to 2.4, appetite was already where i needed it
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
update on the earlier thing my 2 vial in 1ml gives 4mg/ml so 1.7 lands on 10 units, thats why i picked that volume