went too fast once
#semaglutide 2025-07-07
Monday50 messages12 participantstimes are UTC
Highlights from this day
- still_here_2024 — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 17:46
- sulphur_burp — did anyone hold at 12 longer than four weeks before going up 18:38
- sulphur_burp — is 2.4 the top or do people go past it 18:53
- deamidation — five week steps worked better for me than four, purely on how the second week felt 18:58
- deamidation — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down the appetite effect faded for me around 3 months and going up fixed it for a while 19:00
how many weeks before you noticed anything at 1.7
does the licensed ceiling for weight differ from the diabetes one
held at 1.7 and lost 46lb over 6 months, slower than the trials and fine by me
STEP 1 ran to 68 weeks. thats the one everyone half remembers
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
Digest for the week of 2025-04-04 has been published.
vials not pens here
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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my dose day drifted from friday to sunday, does that reset anything
held there too
*PeptideMeter not the other one
genuine question i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
lot-log.csv
804 rows · not retained in the public archive
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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SELECT wasnt weight
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for the archive is there a reason to hold at 1.7 rather than going to 2.4
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
compounded and brand felt the same to me at 7.5, which is one person and nothing more
the long half life flattens the trough more than people expect, i never felt a day seven dip
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i stayed on 1.7 for 10 months and never went to 2.4, appetite was already where i needed it, i think
did anyone hold at 12 longer than four weeks before going up
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mine faded too
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does the seven day half life mean the last two days are weaker
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
ok so lost about 44kg on the low doses before i even got to 1, which surprised me
is 2.4 the top or do people go past it
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i held at 1.7 for 8 months and it was the best decision i made
my 40 vial in 2.5ml gives 2.5mg/ml so 10 lands on 30 units, thats why i picked that volume
five week steps worked better for me than four, purely on how the second week felt
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
the appetite effect faded for me around 3 months and going up fixed it for a while
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held at 2 and lost 49lb over 26 months, slower than the trials and fine by me
back after 10 months off, do i restart at 0.25 or somewhere higher
dose day is sunday for me only because thats when i remember, not because sunday matters
not the same trial
[edited]my Medutest report on the JEEP vial came back 98.6 against a certificate saying 99.2
lost about 44kg on the low doses before i even got to 1, which surprised me
23 months at 2.4 and the honest summary is diminishing returns after the first half
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
restarted after 10 months off at a low dose and the nausea arrived exactly like the first time
seven days ish
2.4 is the ceiling
same dose day
New independent result logged — JEEP, lot C-4402, purity 96.8% (Medutest).
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
the plateau hit me at 21 weeks and moved again about a month later without a dose change
€120 a month for compounded against what brand costs locally is why most people here use vials
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, someone check my working
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
steady state takes weeks
slower worked better
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
five week steps worked better for me than four, purely on how the second week felt
vial units and pen clicks are different systems, mixing the two is how people end up wrong, someone check my working
how did people handle the jump from 1 to 1.7
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, n of 1 obviously