anyone compared their 2.5 vial dosing against the pen increments
#semaglutide 2025-07-13
Sunday63 messages14 participantstimes are UTC
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how long did the first 12kg take for people at the low doses
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the plateau hit me at 4 weeks and moved again about a month later without a dose change
15 months at 2.4 and the honest summary is diminishing returns after the first half
half life is about a week so youre roughly four to five weeks to steady state on any new dose, anyway
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lost about 26kg on the low doses before i even got to 1, which surprised me
*Janoshik not the other one
what did SELECT actually measure, i see it quoted for everything
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
does the seven day half life mean the last two days are weaker
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
how long till steady state, ive read the half life is about a week
Batch lookup B-0329: 4 independent reports on file, earliest 2025-03-29.
1 months at 2.4 and the honest summary is diminishing returns after the first half, i could be wrong
vial units and pen clicks are different systems, mixing the two is how people end up wrong
my dose day drifted from friday to sunday, does that reset anything
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slightly off topic but changed my mind on the four week rule, i think it depends entirely on how the current dose feels
[edited]the long half life flattens the trough more than people expect, i never felt a day seven dip, ill dig out the number
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did anyone titrate slower than four weeks a step and how did that go
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
fridge-temps.csv
753 rows · not retained in the public archive
anyone gone from 1.7 straight to 2.5 or is that too big a jump
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SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
went too fast once
plateaus move
im at 12 and stuck, did anyone break a plateau without going up
STEP is several trials, so saying STEP said x is usually wrong without a number after it, from memory
i dont think the plateau is a dose problem most of the time, but i cant prove that
held at 1.7 and lost 14lb over 17 months, slower than the trials and fine by me
compounded and brand felt the same to me at 2, which is one person and nothing more, anyway
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moving my dose day by a day or two never did anything noticeable for me, still working it out
is the plateau usually appetite coming back or just the scale stopping
steady state takes weeks
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is 2.4 the top or do people go past it
*Janoshik not the other one
does the licensed ceiling for weight differ from the diabetes one
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
did the STEP 4 withdrawal arm show what i think it showed
*Janoshik not the other one
same dose day, someone check my working
i held at 1.7 for 4 months and it was the best decision i made, thats just me
i stayed on 1.7 for 8 months and never went to 2.4, appetite was already where i needed it
my 10 vial in 1ml gives 10mg/ml so 2.5 lands on 50 units, thats why i picked that volume
STEP 1 ran to 68 weeks. thats the one everyone half remembers
update on the earlier thing my 5 vial in 3ml gives 2mg/ml so 15 lands on 12 units, thats why i picked that volume, not advice obviously
mine faded too
give it four weeks
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
the appetite effect faded for me around 8 months and going up fixed it for a while
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
seven days ish
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my Medutest report on the QST vial came back 98.1 against a certificate saying 99.4
2.4 is the ceiling
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
slower worked better, from memory
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
is the plateau at 16 weeks normal or am i doing something wrong
$185 a month for compounded against what brand costs locally is why most people here use vials
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back after 18 months off, do i restart at 0.25 or somewhere higher
for the archive did anybody find a difference between MKM and pharmacy at the same 2
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgi was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
Reminder for step_one_sian: dose day is today. Set 7 days ago.
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, thats just me
held there too
not the same trial
thats STEP 1
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was STEP 4 the one that ran to 68 weeks or am i mixing them up