not the same trial
#semaglutide 2025-07-15
Tuesday35 messages7 participantstimes are UTC
Highlights from this day
- question_queue — half life is about a week so youre roughly four to five weeks to steady state on any new dose 14:30
- question_queue — genuine question does the licensed ceiling for weight differ from the diabetes one 15:23
- question_queue — dose day is sunday for me only because thats when i remember, not because sunday matters, ask me again in a month i was wrong about the ceiling for a year, i thought… 15:41
- lower_frequency — did anyone titrate slower than four weeks a step and how did that go 16:07
seven days ish
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
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back after 7 months off, do i restart at 0.25 or somewhere higher
how long till steady state, ive read the half life is about a week
mine faded too
vial units and pen clicks are different systems, mixing the two is how people end up wrong
genuine question does the licensed ceiling for weight differ from the diabetes one
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is 2.4 the top or do people go past it
five week steps worked better for me than four, purely on how the second week felt
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, your mileage will differ
dose day is sunday for me only because thats when i remember, not because sunday matters, ask me again in a month
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgunrelated but how long did the first 31kg take for people at the low doses
SELECT wasnt weight
genuine question STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
[edited]held there too
did anyone titrate slower than four weeks a step and how did that go
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coming back to this restarted after 13 months off at a low dose and the nausea arrived exactly like the first time, for what its worth
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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thats STEP 1
plateaus move
what did SELECT actually measure, i see it quoted for everything
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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same dose day
slower worked better
is the plateau usually appetite coming back or just the scale stopping
went too fast once
Inter-lab diff for lot D-0718: 97.4% vs 99.2%. Within expected range.
give it four weeks
weights-monthly.csv
527 rows · not retained in the public archive
anyone gone from 1 straight to 10 or is that too big a jump
2.4 is the ceiling
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
did anyone hold at 2 longer than four weeks before going up
does moving my dose day by two days matter with a seven day half life
my VendorInvestigate report on the BCH vial came back 99.4 against a certificate saying 98.1
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
does anyone actually run a five week step instead of four