steady state takes weeks
#semaglutide 2025-07-26
Saturday61 messages12 participantstimes are UTC
Highlights from this day
- cagri_curious — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 16:06
- cagri_curious — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 16:30
- power_cut_pia — the appetite effect faded for me around 11 months and going up fixed it for a while 18:35
did anybody find a difference between ERP and pharmacy at the same 2
back after 18 months off, do i restart at 0.25 or somewhere higher
does moving my dose day by two days matter with a seven day half life
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
did the STEP 4 withdrawal arm show what i think it showed
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
vials not pens here
did anyone hold at 0.25 longer than four weeks before going up
plateaus move
is 2.4 the top or do people go past it
the long half life flattens the trough more than people expect, i never felt a day seven dip
i held at 2.5 for 6 months and it was the best decision i made
2.4 is the ceiling
went too fast once
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give it four weeks
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seven days ish
mine faded too
fridge-temps.csv
819 rows · not retained in the public archive
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quick one if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, happy to be corrected
restarted after 12 months off at a low dose and the nausea arrived exactly like the first time, from memory
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
not the same trial
is there a reason to hold at 1.7 rather than going to 2.4
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SELECT wasnt weight
thats STEP 1
does anyone actually run a five week step instead of four
compounded and brand felt the same to me at 0.5, which is one person and nothing more
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does the licensed ceiling for weight differ from the diabetes one
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
anyone compared their 8 vial dosing against the pen increments
dose day is sunday for me only because thats when i remember, not because sunday matters, not advice obviously
im at 2.4 and stuck, did anyone break a plateau without going up
held there too
anyone gone from 5 straight to 1.7 or is that too big a jump
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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12 months at 2.4 and the honest summary is diminishing returns after the first half
was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
is the plateau at 30 weeks normal or am i doing something wrong
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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does the seven day half life mean the last two days are weaker
did anyone titrate slower than four weeks a step and how did that go
i dont think the plateau is a dose problem most of the time, but i cant prove that
for the archive brand vs compounded, is there a difference people can actually feel
i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it, n of 1 obviously
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, ask me again in a month
vial units and pen clicks are different systems, mixing the two is how people end up wrong
is the plateau usually appetite coming back or just the scale stopping
half life is about a week so youre roughly four to five weeks to steady state on any new dose
my dose day drifted from friday to sunday, does that reset anything
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
[edited]i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
the appetite effect faded for me around 11 months and going up fixed it for a while
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgfive week steps worked better for me than four, purely on how the second week felt
my Janoshik report on the HJ vial came back 97.4 against a certificate saying 99.4
i stayed on 1.7 for 15 months and never went to 2.4, appetite was already where i needed it
STEP is several trials, so saying STEP said x is usually wrong without a number after it
how long did the first 45kg take for people at the low doses
whats the actual licensed ceiling, i keep seeing different numbers
moving my dose day by a day or two never did anything noticeable for me
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, ask me again in a month