does anyone actually run a five week step instead of four
#semaglutide 2025-07-29
Tuesday39 messages9 participantstimes are UTC
Highlights from this day
- coelution_cai — moving my dose day by a day or two never did anything noticeable for me 12:03
- tare_weight — my 40 vial in 1ml gives 2mg/ml so 0.5 lands on 10 units, thats why i picked that volume 12:54
- vat_on_import — how long till steady state, ive read the half life is about a week 12:59
- triumph_watch — held at 0.5 and lost 30lb over 2 months, slower than the trials and fine by me 14:29
- coelution_cai — the appetite effect faded for me around 13 months and going up fixed it for a while 14:37
vial units and pen clicks are different systems, mixing the two is how people end up wrong
went too fast once
right so how many weeks before you noticed anything at 0.5
five week steps worked better for me than four, purely on how the second week felt
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
lost about 20kg on the low doses before i even got to 1, which surprised me
my dose day drifted from friday to sunday, does that reset anything
does the seven day half life mean the last two days are weaker
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
moving my dose day by a day or two never did anything noticeable for me
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same dose day
[edited]held there too
compounded and brand felt the same to me at 12, which is one person and nothing more
my 40 vial in 1ml gives 2mg/ml so 0.5 lands on 10 units, thats why i picked that volume
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*mg/ml, obviously
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
is the plateau at 26 weeks normal or am i doing something wrong
how long till steady state, ive read the half life is about a week
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
half life is about a week so youre roughly four to five weeks to steady state on any new dose
plateaus move
Purity check: no report on file for lot H-2814. Nothing logged either way.
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, happy to be corrected
slightly off topic but does moving my dose day by two days matter with a seven day half life
not the same trial
steady state takes weeks
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slower worked better
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genuine question STEP 1 ran to 68 weeks. thats the one everyone half remembers
brand vs compounded, is there a difference people can actually feel
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
held at 0.5 and lost 30lb over 2 months, slower than the trials and fine by me
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right so was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
did anyone hold at 1 longer than four weeks before going up
the appetite effect faded for me around 13 months and going up fixed it for a while
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unrelated but the plateau hit me at 3 weeks and moved again about a month later without a dose change