how long till steady state, ive read the half life is about a week
#semaglutide 2025-07-28
Monday45 messages10 participantstimes are UTC
Highlights from this day
- mg_per_ml — follow up i dont think the plateau is a dose problem most of the time, but i cant prove that 17:40
- blank_run — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, anyway 18:53
- blank_run — while im here compounded and brand felt the same to me at 1, which is one person and nothing more 19:33
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
is 2.4 the top or do people go past it
brand vs compounded, is there a difference people can actually feel
im at 1 and stuck, did anyone break a plateau without going up
half life is about a week so youre roughly four to five weeks to steady state on any new dose
what did SELECT actually measure, i see it quoted for everything
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
does the seven day half life mean the last two days are weaker
how long did the first 48kg take for people at the low doses
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
steady state takes weeks
does moving my dose day by two days matter with a seven day half life
did anyone titrate slower than four weeks a step and how did that go
anyone compared their 2 vial dosing against the pen increments
did anyone hold at 1.7 longer than four weeks before going up
group_buy_gwenchanged my mind on the four week rule, i think it depends entirely on how the current…
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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is the plateau at 3 weeks normal or am i doing something wrong
is the plateau usually appetite coming back or just the scale stopping
the plateau hit me at 8 weeks and moved again about a month later without a dose change
not the same trial
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
STEP 1 ran to 68 weeks. thats the one everyone half remembers
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
follow up i dont think the plateau is a dose problem most of the time, but i cant prove that
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mggenuine question the appetite effect faded for me around 25 months and going up fixed it for a while
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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is there a reason to hold at 1.7 rather than going to 2.4
vial units and pen clicks are different systems, mixing the two is how people end up wrong
my dose day drifted from friday to sunday, does that reset anything
dose day is sunday for me only because thats when i remember, not because sunday matters, from memory
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, anyway
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right so i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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while im here was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
SELECT wasnt weight
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
back after 23 months off, do i restart at 0.25 or somewhere higher
seven days ish
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgvials not pens here
my 10 vial in 2.5ml gives 8mg/ml so 2.4 lands on 25 units, thats why i picked that volume
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whats the actual licensed ceiling, i keep seeing different numbers
while im here compounded and brand felt the same to me at 1, which is one person and nothing more
*VendorInvestigate not the other one
held there too
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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