restarted after 11 months off at a low dose and the nausea arrived exactly like the first time
#semaglutide 2025-08-16
Saturday59 messages9 participantstimes are UTC
Highlights from this day
- cold_pack_carla — moving my dose day by a day or two never did anything noticeable for me, thats one data point 17:13
- cold_pack_carla — STEP is several trials, so saying STEP said x is usually wrong without a number after it 17:37
- a1c_lag — STEP 1 ran to 68 weeks. thats the one everyone half remembers 18:15
- deamidation — brand vs compounded, is there a difference people can actually feel 18:31
- cat_on_the_tray — does the seven day half life mean the last two days are weaker 20:23
the long half life flattens the trough more than people expect, i never felt a day seven dip
plateaus move
2.4 is the ceiling
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while im here changed my mind on the four week rule, i think it depends entirely on how the current dose feels
my Janoshik report on the JEEP vial came back 97.4 against a certificate saying 99.4, ill dig out the number
is there a reason to hold at 1.7 rather than going to 2.4
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
vial units and pen clicks are different systems, mixing the two is how people end up wrong
i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it
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not the same trial
held there too
i dont think the plateau is a dose problem most of the time, but i cant prove that
how many weeks before you noticed anything at 0.25
sorry to jump in anyone gone from 0.5 straight to 1.7 or is that too big a jump
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
did anybody find a difference between SSA and pharmacy at the same 1
coming back to this compounded and brand felt the same to me at 10, which is one person and nothing more
[edited]half life is about a week so youre roughly four to five weeks to steady state on any new dose, take that with a pinch of salt
is the plateau usually appetite coming back or just the scale stopping
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
moving my dose day by a day or two never did anything noticeable for me, thats one data point
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
steady state takes weeks
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went too fast once
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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seven days ish
[edited]give it four weeks
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
my 5 vial in 1ml gives 10mg/ml so 1 lands on 25 units, thats why i picked that volume
right so i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
€55 a month for compounded against what brand costs locally is why most people here use vials
[edited]how did people handle the jump from 1 to 1.7
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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five week steps worked better for me than four, purely on how the second week felt
the plateau hit me at 30 weeks and moved again about a month later without a dose change
brand vs compounded, is there a difference people can actually feel
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unrelated but im at 7.5 and stuck, did anyone break a plateau without going up
thats STEP 1
did the STEP 4 withdrawal arm show what i think it showed
[edited]cold_pack_carlamy 5 vial in 1ml gives 10mg/ml so 1 lands on 25 units, thats why i picked that volume
sorry to jump in im 9 months in at 2 and the appetite effect faded, is that a thing
vials not pens here
dose day is sunday for me only because thats when i remember, not because sunday matters
for the archive going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
how long did the first 19kg take for people at the low doses
whats the actual licensed ceiling, i keep seeing different numbers
i held at 7.5 for 4 months and it was the best decision i made
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, from memory
the appetite effect faded for me around 8 months and going up fixed it for a while
SELECT wasnt weight
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, take that with a pinch of salt
24 months at 2.4 and the honest summary is diminishing returns after the first half, take that with a pinch of salt
same dose day
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moving my dose day by a day or two never did anything noticeable for me
is the plateau at 26 weeks normal or am i doing something wrong
does the seven day half life mean the last two days are weaker
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anyone compared their 2.5 vial dosing against the pen increments