back after 9 months off, do i restart at 0.25 or somewhere higher
#semaglutide 2025-08-18
Monday51 messages12 participantstimes are UTC
Highlights from this day
- first_and_last_four — right so lost about 30kg on the low doses before i even got to 1, which surprised me 10:10
- VialBot — New independent result logged — QSC, lot SG-1177, purity 99.2% (Medutest). 11:34
- forty_units — does the seven day half life mean the last two days are weaker 13:58
- baseline_drift — sorry to jump in i stayed on 1.7 for 17 months and never went to 2.4, appetite was already where i needed it 14:56
mine faded too
the appetite effect faded for me around 14 months and going up fixed it for a while
STEP 1 ran to 68 weeks. thats the one everyone half remembers
[edited]right so lost about 30kg on the low doses before i even got to 1, which surprised me
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
same dose day
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does anyone actually run a five week step instead of four
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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anyone compared their 4 vial dosing against the pen increments
not the same trial
how did people handle the jump from 1 to 1.7
plateaus move
give it four weeks
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
i stayed on 1.7 for 23 months and never went to 2.4, appetite was already where i needed it
2.4 is the ceiling
for the archive SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, for what its worth
moving my dose day by a day or two never did anything noticeable for me
anyone gone from 15 straight to 7.5 or is that too big a jump
is the plateau at 28 weeks normal or am i doing something wrong
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgNew independent result logged — QSC, lot SG-1177, purity 99.2% (Medutest).
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my Janoshik report on the SGN vial came back 97.4 against a certificate saying 99.4
steady state takes weeks
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five week steps worked better for me than four, purely on how the second week felt
£94 a month for compounded against what brand costs locally is why most people here use vials
the long half life flattens the trough more than people expect, i never felt a day seven dip, i have it written down somewhere
slower worked better
slightly off topic but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
seven days ish
went too fast once
thats STEP 1
vials not pens here
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held there too
is there a reason to hold at 1.7 rather than going to 2.4
dose day is sunday for me only because thats when i remember, not because sunday matters
does the seven day half life mean the last two days are weaker
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
sorry to jump in my dose day drifted from friday to sunday, does that reset anything
sorry to jump in i stayed on 1.7 for 17 months and never went to 2.4, appetite was already where i needed it
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did anybody find a difference between CPC and pharmacy at the same 10
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
restarted after 8 months off at a low dose and the nausea arrived exactly like the first time
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
what did SELECT actually measure, i see it quoted for everything
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
whats the actual licensed ceiling, i keep seeing different numbers
my 20 vial in 1ml gives 2.5mg/ml so 1 lands on 8 units, thats why i picked that volume
held at 0.25 and lost 103lb over 16 months, slower than the trials and fine by me
SELECT wasnt weight
right so did anyone titrate slower than four weeks a step and how did that go
how long did the first 13kg take for people at the low doses