ok so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
#semaglutide 2025-08-22
Friday40 messages8 participantstimes are UTC
Highlights from this day
- lipase_lore — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 22:34
- nordic_price_nils — back after 13 months off, do i restart at 0.25 or somewhere higher my Medutest report on the QSC vial came back 99.4 against a certificate saying 99 22:44
- split_dose_sam — did anybody find a difference between Homopeptide and pharmacy at the same 12 22:57
- split_dose_sam — STEP is several trials, so saying STEP said x is usually wrong without a number after it 22:59
- meal_prep_mick — does the licensed ceiling for weight differ from the diabetes one 23:22
what did SELECT actually measure, i see it quoted for everything
thats STEP 1
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
give it four weeks
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plateaus move
$94 a month for compounded against what brand costs locally is why most people here use vials, someone check my working
held there too
i stayed on 1.7 for 21 months and never went to 2.4, appetite was already where i needed it
back after 13 months off, do i restart at 0.25 or somewhere higher
my Medutest report on the QSC vial came back 99.4 against a certificate saying 99
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how many weeks before you noticed anything at 10
STEP 1 ran to 68 weeks. thats the one everyone half remembers
seven days ish
my 20 vial in 5ml gives 2mg/ml so 1 lands on 15 units, thats why i picked that volume, your mileage will differ
moving my dose day by a day or two never did anything noticeable for me
did anyone hold at 5 longer than four weeks before going up
is 2.4 the top or do people go past it
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, someone check my working
did anybody find a difference between Homopeptide and pharmacy at the same 12
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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i dont think the plateau is a dose problem most of the time, but i cant prove that, thats just me
SELECT wasnt weight
was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
unrelated but brand vs compounded, is there a difference people can actually feel
did the STEP 4 withdrawal arm show what i think it showed
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
vials not pens here
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five week steps worked better for me than four, purely on how the second week felt
slower worked better
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
does the licensed ceiling for weight differ from the diabetes one
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went too fast once
steady state takes weeks
[edited]STEP 1 ran to 68 weeks. thats the one everyone half remembers
restarted after 8 months off at a low dose and the nausea arrived exactly like the first time
STEP is several trials, so saying STEP said x is usually wrong without a number after it
*VendorInvestigate not the other one
2.4 is the ceiling
same dose day
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my dose day drifted from friday to sunday, does that reset anything
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
not the same trial
im at 2.4 and stuck, did anyone break a plateau without going up