steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
#semaglutide 2025-09-17
Wednesday41 messages9 participantstimes are UTC
Highlights from this day
- blank_run — rough accumulation if you inject the same amount weekly and the half-life is 7 days 22:50
- retention_time — this should be pinned honestly 22:54
- blank_run — i cant tell you that and i wont. what i can tell you is what the curve looks like, and it looks like you have not seen the top of your current dose yet 23:19
- VialBot — reminder for @reading_the_pins (set 12 days ago): you asked to be pinged to log how week 4 went. #dosing-titration 23:58
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, still working it out
half life is about a week so youre roughly four to five weeks to steady state on any new dose
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
how many weeks before you noticed anything at 12
how long till steady state, ive read the half life is about a week
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my dose day drifted from friday to sunday, does that reset anything
restarted after 4 months off at a low dose and the nausea arrived exactly like the first time
my Medutest report on the GGPeps vial came back 98.6 against a certificate saying 99.4
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
is the plateau usually appetite coming back or just the scale stopping
i moved up two weeks ago and felt nothing for the first week then got hit hard. is that normal
extremely. the half-life is about a week
so a dose change is not an event, its a slow slope you walk up for about a month
a month??
rough accumulation if you inject the same amount weekly and the half-life is 7 days
week 1 dose lands -> 1.00 units of "stuff"
week 2 0.50 left + 1.00 new = 1.50
week 3 0.75 + 1.00 = 1.75
week 4 0.88 + 1.00 = 1.88
week 5 0.94 + 1.00 = 1.94
week 6 0.97 + 1.00 = 1.97
plateau = 2.00
so ~95% of the way there by week 5. that is where the
"give it 4 to 5 weeks" advice comes from. it is not folklore,
it is just doubling.this should be pinned honestly
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so the nausea at day 9 was from dose 2 or dose 1
both. thats the whole point. you are never on one dose, you are on the sum of the last several
which is also why moving up every 2 weeks is a slightly odd thing to do
you are changing the input before you have seen the output of the last change
the 4 week steps in the label are not arbitrary
i was told 2 weeks was fine if you feel ok
you might be. you just wont know whether you were until three weeks after you find out
cheerful
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ok so what do i do now, hold or drop
i cant tell you that and i wont. what i can tell you is what the curve looks like, and it looks like you have not seen the top of your current dose yet
my own rule, for me, was never change anything in the same week i changed something
afk, dog
how long did you sit at each step
5 weeks minimum. i was slower than the label. took me nearly 7 months to reach 2.4
and did that cost you anything
about four months of impatience and nothing else
back. also worth knowing the half-life is why a missed day barely registers
one day late on a 7 day half-life is nothing. three days late is noticeable. that is the whole injection day drift argument
going back to the week half-life thing — does that mean if i stopped entirely it takes weeks to clear too
yes. five weeks up, roughly five weeks down. people are always surprised by the down side and it is exactly the same arithmetic
reminder for @reading_the_pins (set 12 days ago): you asked to be pinged to log how week 4 went. #dosing-titration
the bot has receipts
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the bot always has receipts