sorry to jump in i dont think the plateau is a dose problem most of the time, but i cant prove that
#semaglutide 2025-09-18
Thursday61 messages14 participantstimes are UTC
Highlights from this day
- sgp_subq — follow up whats the actual licensed ceiling, i keep seeing different numbers 22:19
- gradient_greg — the appetite effect faded for me around 22 months and going up fixed it for a while, ill dig out the number 22:39
- sgp_subq — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 23:15
- VialBot — Assay note: QYB lot G-0641 reported at 98.1% of label content. 23:16
while im here i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
plateaus move
i held at 1.7 for 3 months and it was the best decision i made, i have it written down somewhere
did the STEP 4 withdrawal arm show what i think it showed
lost about 29kg on the low doses before i even got to 1, which surprised me
coming back to this moving my dose day by a day or two never did anything noticeable for me
sorry to jump in does anyone actually run a five week step instead of four
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*week 33 not week 9
ok so i stayed on 1.7 for 12 months and never went to 2.4, appetite was already where i needed it
anyone gone from 1.7 straight to 7.5 or is that too big a jump
restarted after 3 months off at a low dose and the nausea arrived exactly like the first time
the plateau hit me at 18 weeks and moved again about a month later without a dose change
*Janoshik not the other one
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
steady state takes weeks
went too fast once
same dose day
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mggoing slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
[edited]five week steps worked better for me than four, purely on how the second week felt
follow up whats the actual licensed ceiling, i keep seeing different numbers
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does the seven day half life mean the last two days are weaker
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
restarted after 15 months off at a low dose and the nausea arrived exactly like the first time
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the long half life flattens the trough more than people expect, i never felt a day seven dip
did anyone hold at 7.5 longer than four weeks before going up
[edited]did anybody find a difference between SSA and pharmacy at the same 1.7
how long did the first 28kg take for people at the low doses
*PeptideMeter not the other one
does moving my dose day by two days matter with a seven day half life
vial units and pen clicks are different systems, mixing the two is how people end up wrong
janoshik-f-1330.pdf
2 pages · 332 KB · not retained in the public archive
half life is about a week so youre roughly four to five weeks to steady state on any new dose
my 40 vial in 1ml gives 5mg/ml so 0.25 lands on 10 units, thats why i picked that volume
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the appetite effect faded for me around 22 months and going up fixed it for a while, ill dig out the number
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not the same trial
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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how did people handle the jump from 1 to 1.7
moving my dose day by a day or two never did anything noticeable for me
did anyone titrate slower than four weeks a step and how did that go
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
lot-log.csv
572 rows · not retained in the public archive
is the plateau at 20 weeks normal or am i doing something wrong
thats STEP 1
is there a reason to hold at 1.7 rather than going to 2.4
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
half life is about a week so youre roughly four to five weeks to steady state on any new dose
brand vs compounded, is there a difference people can actually feel
SELECT wasnt weight
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im at 2.5 and stuck, did anyone break a plateau without going up
update on the earlier thing 17 months at 2.4 and the honest summary is diminishing returns after the first half
update on the earlier thing SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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Assay note: QYB lot G-0641 reported at 98.1% of label content.
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
my dose day drifted from friday to sunday, does that reset anything
€120 a month for compounded against what brand costs locally is why most people here use vials, from memory
the appetite effect faded for me around 7 months and going up fixed it for a while
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
STEP is several trials, so saying STEP said x is usually wrong without a number after it
dose day is sunday for me only because thats when i remember, not because sunday matters
STEP 1 ran to 68 weeks. thats the one everyone half remembers
[edited]give it four weeks
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgcoming back to this im 3 months in at 2 and the appetite effect faded, is that a thing
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was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
vials not pens here
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
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