slower worked better
#semaglutide 2025-09-24
Wednesday45 messages9 participantstimes are UTC
Highlights from this day
- cagri_curious — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 17:56
- sharps_bin_sid — right so if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, i could be wrong 18:34
- seizure_letter — unrelated but whats the actual licensed ceiling, i keep seeing different numbers 19:56
im at 2 and stuck, did anyone break a plateau without going up
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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steady state takes weeks
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
went too fast once
mine faded too
right so if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, i could be wrong
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moving my dose day by a day or two never did anything noticeable for me
did anybody find a difference between FGP and pharmacy at the same 0.25
i held at 2.5 for 6 months and it was the best decision i made
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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slightly off topic but 13 months at 2.4 and the honest summary is diminishing returns after the first half
while im here licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
did anyone titrate slower than four weeks a step and how did that go
ok so going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
€38 a month for compounded against what brand costs locally is why most people here use vials
STEP 1 ran to 68 weeks. thats the one everyone half remembers
follow up my dose day drifted from friday to sunday, does that reset anything
STEP is several trials, so saying STEP said x is usually wrong without a number after it
slightly off topic but did the STEP 4 withdrawal arm show what i think it showed
plateaus move
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does anyone actually run a five week step instead of four
anyone gone from 12 straight to 1.7 or is that too big a jump
unrelated but whats the actual licensed ceiling, i keep seeing different numbers
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
compounded and brand felt the same to me at 2, which is one person and nothing more
lost about 15kg on the low doses before i even got to 1, which surprised me
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my 5 vial in 1ml gives 10mg/ml so 2 lands on 12 units, thats why i picked that volume
same dose day
how long till steady state, ive read the half life is about a week
my PeptideMeter report on the QSC vial came back 96.8 against a certificate saying 99.4
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
my Medutest report on the FGP vial came back 98.1 against a certificate saying 97.4
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
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seven days ish
thats STEP 1
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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*Medutest not the other one
vials not pens here
five week steps worked better for me than four, purely on how the second week felt
for the archive does the licensed ceiling for weight differ from the diabetes one
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give it four weeks
2.4 is the ceiling