the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, ymmv
5 months at 2.4 and the honest summary is diminishing returns after the first half
#semaglutide 2025-09-28
Sunday16 messages5 participantstimes are UTC
Highlights from this day
- mid_week_mo — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, ymmv 5 months at 2.4 and the honest summary is diminishing returns… 14:33
- bengaluru_bac — the appetite effect faded for me around 12 months and going up fixed it for a while going slow cost me nothing except time and saved me two bad weeks, thats my whole… 15:33
- bengaluru_bac — i stayed on 1.7 for 24 months and never went to 2.4, appetite was already where i needed it, someone check my working 15:55
- verify_or_dont — update on the earlier thing compounded and brand felt the same to me at 1, which is one person and nothing more 16:43
- relabel_watch — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution STEP 1 ran to 68 weeks. thats the one everyone half remembers 17:46
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
half life is about a week so youre roughly four to five weeks to steady state on any new dose
does the seven day half life mean the last two days are weaker
seven days ish
plateaus move
the appetite effect faded for me around 12 months and going up fixed it for a while
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
i stayed on 1.7 for 24 months and never went to 2.4, appetite was already where i needed it, someone check my working
thats STEP 1
did anyone hold at 0.25 longer than four weeks before going up
update on the earlier thing compounded and brand felt the same to me at 1, which is one person and nothing more
what did SELECT actually measure, i see it quoted for everything
im at 2.5 and stuck, did anyone break a plateau without going up
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
give it four weeks
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
STEP 1 ran to 68 weeks. thats the one everyone half remembers