sorry to jump in going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
#semaglutide 2025-10-01
Wednesday50 messages11 participantstimes are UTC
Highlights from this day
- baseline_drift — five week steps worked better for me than four, purely on how the second week felt 22:31
- two_four_ceiling — slightly off topic but STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 23:01
- dog_person_dev — my dose day drifted from friday to sunday, does that reset anything 23:11
- reta_resting_hr — how did people handle the jump from 1 to 1.7 23:21
- half_life_hal — anyone compared their 8 vial dosing against the pen increments 23:40
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
did anyone hold at 10 longer than four weeks before going up
is the plateau at 31 weeks normal or am i doing something wrong
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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vials not pens here
half life is about a week so youre roughly four to five weeks to steady state on any new dose
compounded and brand felt the same to me at 1.7, which is one person and nothing more
20 months at 2.4 and the honest summary is diminishing returns after the first half
[edited]held at 12 and lost 29lb over 15 months, slower than the trials and fine by me
five week steps worked better for me than four, purely on how the second week felt
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sorry to jump in i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
dose day is sunday for me only because thats when i remember, not because sunday matters, thats just me
did anyone titrate slower than four weeks a step and how did that go
SELECT wasnt weight
the long half life flattens the trough more than people expect, i never felt a day seven dip
2.4 is the ceiling
lost about 5kg on the low doses before i even got to 1, which surprised me
while im here back after 20 months off, do i restart at 0.25 or somewhere higher
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
sorry to jump in the plateau hit me at 22 weeks and moved again about a month later without a dose change
slightly off topic but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
STEP 1 ran to 68 weeks. thats the one everyone half remembers
[edited]slower worked better
thats STEP 1
slightly off topic but STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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is there a reason to hold at 1.7 rather than going to 2.4
23:05ferrous_ash pinned a message to this channel
how long did the first 9kg take for people at the low doses
did anybody find a difference between CPC and pharmacy at the same 2.4
my dose day drifted from friday to sunday, does that reset anything
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give it four weeks
plateaus move
quick one moving my dose day by a day or two never did anything noticeable for me
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im 25 months in at 12 and the appetite effect faded, is that a thing
how did people handle the jump from 1 to 1.7
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
anyone gone from 15 straight to 0.25 or is that too big a jump
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
mine faded too
does anyone actually run a five week step instead of four
same dose day
anyone compared their 8 vial dosing against the pen increments
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
vial units and pen clicks are different systems, mixing the two is how people end up wrong
went too fast once
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