vialroom

#semaglutide 2025-10-04

Saturday24 messages7 participantstimes are UTC
Highlights from this day
  • orfor_watch — my dose day drifted from friday to sunday, does that reset anything 09:19
  • orfor_watch — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 09:29
  • hot_mailbox — vial units and pen clicks are different systems, mixing the two is how people end up wrong 09:39
  • orfor_watch — my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 10:42
  • orfor_watch — brand vs compounded, is there a difference people can actually feel 12:18
OW

my dose day drifted from friday to sunday, does that reset anything

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OW

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

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HM

vial units and pen clicks are different systems, mixing the two is how people end up wrong

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OW

4 months at 2.4 and the honest summary is diminishing returns after the first half

OO

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

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OW

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

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FT

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

AO

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

HM

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

AO

for the archive im at 1 and stuck, did anyone break a plateau without going up

AO

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

HM

did anyone hold at 0.25 longer than four weeks before going up

HM

give it four weeks

Cited study
Semaglutide vs Liraglutide for Weight Loss in Adults with Overweight or Obesity (STEP 8)
JAMA · 2022
Weekly against daily, head to head.

compounded and brand felt the same to me at 5, which is one person and nothing more

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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

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OW

brand vs compounded, is there a difference people can actually feel

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OW

the plateau hit me at 27 weeks and moved again about a month later without a dose change