same dose day
🧪8👍1❤️10
#semaglutide 2025-10-05
Sunday55 messages14 participantstimes are UTC
Highlights from this day
- tallinn_taper — lost about 16kg on the low doses before i even got to 1, which surprised me 09:06
- week_three_wall — vial units and pen clicks are different systems, mixing the two is how people end up wrong 11:11
- leeds_ledger — follow up my 2 vial in 2ml gives 5mg/ml so 2 lands on 25 units, thats why i picked that volume 14:48
plateaus move
what did SELECT actually measure, i see it quoted for everything
lost about 16kg on the low doses before i even got to 1, which surprised me
[edited]🤝1🎉15
right so held at 7.5 and lost 81lb over 20 months, slower than the trials and fine by me
seven days ish
sorry to jump in half life is about a week so youre roughly four to five weeks to steady state on any new dose, someone check my working
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
vials not pens here
🔥14
2.4 is the ceiling
Purity check: no report on file for lot B-0329. Nothing logged either way.
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, from memory
give it four weeks
[edited]if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
sorry to jump in 26 months at 2.4 and the honest summary is diminishing returns after the first half
the plateau hit me at 34 weeks and moved again about a month later without a dose change
📉3
moving my dose day by a day or two never did anything noticeable for me
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
anyone compared their 2.5 vial dosing against the pen increments
vial units and pen clicks are different systems, mixing the two is how people end up wrong
🤝15🔥3
slower worked better
thats STEP 1
🤝14
STEP is several trials, so saying STEP said x is usually wrong without a number after it, someone check my working
steady state takes weeks
ok so whats the actual licensed ceiling, i keep seeing different numbers
did the STEP 4 withdrawal arm show what i think it showed
im 10 months in at 12 and the appetite effect faded, is that a thing
does anyone actually run a five week step instead of four
my dose day drifted from friday to sunday, does that reset anything
tallinn_taperright so held at 7.5 and lost 81lb over 20 months, slower than the trials and fine by me
STEP 1 ran to 68 weeks. thats the one everyone half remembers
back after 14 months off, do i restart at 0.25 or somewhere higher
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
[edited]wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgdid anyone hold at 2.5 longer than four weeks before going up
does the licensed ceiling for weight differ from the diabetes one
is the plateau usually appetite coming back or just the scale stopping
[edited]anyone gone from 0.25 straight to 1.7 or is that too big a jump
went too fast once
i held at 2.5 for 8 months and it was the best decision i made
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
SELECT wasnt weight
follow up my 2 vial in 2ml gives 5mg/ml so 2 lands on 25 units, thats why i picked that volume
📈2🧪1🧊12
dose day is sunday for me only because thats when i remember, not because sunday matters
slightly off topic but i stayed on 1.7 for 26 months and never went to 2.4, appetite was already where i needed it
unrelated but im at 2.4 and stuck, did anyone break a plateau without going up
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i dont think the plateau is a dose problem most of the time, but i cant prove that
🎉5✅1
compounded and brand felt the same to me at 15, which is one person and nothing more
mine faded too
brand vs compounded, is there a difference people can actually feel
the appetite effect faded for me around 1 months and going up fixed it for a while
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
restarted after 25 months off at a low dose and the nausea arrived exactly like the first time
does moving my dose day by two days matter with a seven day half life
[edited]was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
❤️1🙏7
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution