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#semaglutide 2025-10-13

Monday37 messages10 participantstimes are UTC
Highlights from this day
  • amylin_amy — coming back to this held at 1 and lost 44lb over 1 months, slower than the trials and fine by me 09:55
  • cold_chain_cmdr — coming back to this vial units and pen clicks are different systems, mixing the two is how people end up wrong 10:44
  • mira_pins — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 12:54
SF

dose day is sunday for me only because thats when i remember, not because sunday matters

AA

coming back to this held at 1 and lost 44lb over 1 months, slower than the trials and fine by me

🎉16📈17
VB

Verification log updated: ERP — evidence added, status unchanged.

WW

lost about 23kg on the low doses before i even got to 1, which surprised me

WW

6 months at 2.4 and the honest summary is diminishing returns after the first half

coming back to this vial units and pen clicks are different systems, mixing the two is how people end up wrong

Cited study
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
New England Journal of Medicine · 2021
68 weeks, semaglutide 2.4mg weekly against placebo, with lifestyle intervention in both arms.

half life is about a week so youre roughly four to five weeks to steady state on any new dose

📈1🧪1🎉2

plateaus move

CC

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

BB

unrelated but i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

BB

changed my mind on the four week rule, i think it depends entirely on how the current dose feels
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

$55 a month for compounded against what brand costs locally is why most people here use vials
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

vials not pens here

[edited]
SF

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

MP

STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping

🙏16

give it four weeks

i held at 2 for 9 months and it was the best decision i made

VO

unrelated but does the licensed ceiling for weight differ from the diabetes one

VO

restarted after 8 months off at a low dose and the nausea arrived exactly like the first time

GG

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

im at 2 and stuck, did anyone break a plateau without going up

VO

my 2 vial in 2.5ml gives 2.5mg/ml so 10 lands on 15 units, thats why i picked that volume

GG

i dont think the plateau is a dose problem most of the time, but i cant prove that

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