SELECT wasnt weight
#semaglutide 2025-11-23
Sunday40 messages9 participantstimes are UTC
Highlights from this day
- homa_ir_hugo — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 18:39
- identity_shift — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 19:14
- bpc_sceptic — STEP 1 ran to 68 weeks. thats the one everyone half remembers 20:06
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
held there too
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im at 2.4 and stuck, did anyone break a plateau without going up
does anyone actually run a five week step instead of four
give it four weeks
restarted after 14 months off at a low dose and the nausea arrived exactly like the first time, for what its worth
was FLOW the one that ran to 68 weeks or am i mixing them up
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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did anyone hold at 15 longer than four weeks before going up
five week steps worked better for me than four, purely on how the second week felt
[edited]*VendorInvestigate not the other one
coming back to this went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
went too fast once
dose day is sunday for me only because thats when i remember, not because sunday matters, your mileage will differ
the long half life flattens the trough more than people expect, i never felt a day seven dip
i held at 0.5 for 6 months and it was the best decision i made
[edited]is there a reason to hold at 1.7 rather than going to 2.4
STEP is several trials, so saying STEP said x is usually wrong without a number after it
my 5 vial in 2ml gives 10mg/ml so 10 lands on 50 units, thats why i picked that volume
STEP 1 ran to 68 weeks. thats the one everyone half remembers
seven days ish
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2.4 is the ceiling
steady state takes weeks
half life is about a week so youre roughly four to five weeks to steady state on any new dose
same dose day
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
does the seven day half life mean the last two days are weaker
my VendorInvestigate report on the QSC vial came back 98.1 against a certificate saying 99
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plateaus move
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
thats STEP 1
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgheld at 5 and lost 88lb over 7 months, slower than the trials and fine by me
compounded and brand felt the same to me at 0.5, which is one person and nothing more
26 months at 2.4 and the honest summary is diminishing returns after the first half
Purity check: no report on file for lot E-2205. Nothing logged either way.
moving my dose day by a day or two never did anything noticeable for me
not the same trial
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