half life is about a week so youre roughly four to five weeks to steady state on any new dose
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#semaglutide 2025-12-09
Tuesday23 messages6 participantstimes are UTC
Highlights from this day
- lisbon_lot — is the plateau at 13 weeks normal or am i doing something wrong SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 13:23
- tokyo_taper — does the licensed ceiling for weight differ from the diabetes one 14:05
- VialBot — Testing queue: 4 submissions open, 56 awaiting dispatch. 15:14
lost about 12kg on the low doses before i even got to 1, which surprised me
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
is the plateau at 13 weeks normal or am i doing something wrong
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, not advice obviously
brand vs compounded, is there a difference people can actually feel
does the licensed ceiling for weight differ from the diabetes one
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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seven days ish
the appetite effect faded for me around 13 months and going up fixed it for a while
is there a reason to hold at 1.7 rather than going to 2.4
Recon calculator: 30mg in 5ml = 2.5mg/ml.
same dose day
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SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
steady state takes weeks
slightly off topic but does anyone actually run a five week step instead of four
*week 28 not week 7
Testing queue: 4 submissions open, 56 awaiting dispatch.
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is the plateau usually appetite coming back or just the scale stopping
*PeptideMeter not the other one
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
anyone gone from 1 straight to 2 or is that too big a jump
how did people handle the jump from 1 to 1.7