slower worked better
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#semaglutide 2025-12-15
Monday56 messages10 participantstimes are UTC
Highlights from this day
- reship_rita — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, not advice obviously 13:42
- reship_rita — €55 a month for compounded against what brand costs locally is why most people here use vials FLOW was the kidney outcomes trial and it gets quoted in here for things… 13:44
- amsterdam_aliquot — did the STEP 4 withdrawal arm show what i think it showed 15:16
- amsterdam_aliquot — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 15:43
- egfr_ed — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 18:36
is the plateau at 20 weeks normal or am i doing something wrong
STEP is several trials, so saying STEP said x is usually wrong without a number after it
im at 15 and stuck, did anyone break a plateau without going up
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the plateau hit me at 7 weeks and moved again about a month later without a dose change
1 months at 2.4 and the honest summary is diminishing returns after the first half
thats STEP 1
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
is the plateau usually appetite coming back or just the scale stopping
is 2.4 the top or do people go past it
im 18 months in at 0.5 and the appetite effect faded, is that a thing
does moving my dose day by two days matter with a seven day half life
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quick one restarted after 18 months off at a low dose and the nausea arrived exactly like the first time, someone check my working
give it four weeks
brand vs compounded, is there a difference people can actually feel
SELECT wasnt weight
[edited]12:54tenpence pinned a message
same dose day
my dose day drifted from friday to sunday, does that reset anything
moving my dose day by a day or two never did anything noticeable for me
five week steps worked better for me than four, purely on how the second week felt
sorry to jump in back after 22 months off, do i restart at 0.25 or somewhere higher
anyone compared their 2 vial dosing against the pen increments
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
vials not pens here
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, not advice obviously
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€55 a month for compounded against what brand costs locally is why most people here use vials
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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was STEP 4 the one that ran to 68 weeks or am i mixing them up
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
mine faded too
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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is there a reason to hold at 1.7 rather than going to 2.4
held there too
ok so does the seven day half life mean the last two days are weaker
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half life is about a week so youre roughly four to five weeks to steady state on any new dose, for what its worth
did the STEP 4 withdrawal arm show what i think it showed
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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dose day is sunday for me only because thats when i remember, not because sunday matters
2.4 is the ceiling
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plateaus move
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lost about 43kg on the low doses before i even got to 1, which surprised me
the appetite effect faded for me around 18 months and going up fixed it for a while
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
what did SELECT actually measure, i see it quoted for everything
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for the archive SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
did anybody find a difference between CPC and pharmacy at the same 1.7
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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did anyone titrate slower than four weeks a step and how did that go
seven days ish
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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does anyone actually run a five week step instead of four
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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quick one mine faded too
medutest-report-h-2814.pdf
3 pages · 293 KB · not retained in the public archive
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
genuine question did anyone hold at 7.5 longer than four weeks before going up
my 20 vial in 3ml gives 8mg/ml so 2 lands on 40 units, thats why i picked that volume