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#semaglutide 2025-12-17

Wednesday23 messages4 participantstimes are UTC
Highlights from this day
  • swab_dry_first — while im here did the STEP 4 withdrawal arm show what i think it showed 16:18
  • swab_dry_first — while im here did anybody find a difference between TFC and pharmacy at the same 2.4 16:28
  • assay_not_purity — how long till steady state, ive read the half life is about a week 16:54
  • assay_not_purity — while im here back after 4 months off, do i restart at 0.25 or somewhere higher 16:59
BR

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

SD

while im here did the STEP 4 withdrawal arm show what i think it showed

1😂10
SD

while im here did anybody find a difference between TFC and pharmacy at the same 2.4

plateaus move

AN

how long till steady state, ive read the half life is about a week

💀18😂1👍1

changed my mind on the four week rule, i think it depends entirely on how the current dose feels, anyway

while im here back after 4 months off, do i restart at 0.25 or somewhere higher

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.

genuine question does the licensed ceiling for weight differ from the diabetes one

not the same trial

i dont think the plateau is a dose problem most of the time, but i cant prove that

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

five week steps worked better for me than four, purely on how the second week felt, take that with a pinch of salt

*that should say weekly

did anyone titrate slower than four weeks a step and how did that go

STEP is several trials, so saying STEP said x is usually wrong without a number after it