£120 a month for compounded against what brand costs locally is why most people here use vials
#semaglutide 2026-01-31
Saturday47 messages10 participantstimes are UTC
Highlights from this day
- fake_tracking — i stayed on 1.7 for 13 months and never went to 2.4, appetite was already where i needed it, not advice obviously 16:12
- electrolyte_eli — vial units and pen clicks are different systems, mixing the two is how people end up wrong 16:51
- electrolyte_eli — does moving my dose day by two days matter with a seven day half life 17:02
- egfr_ed — is there a reason to hold at 1.7 rather than going to 2.4 17:45
- wrong_network — slightly off topic but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 19:51
my Janoshik report on the WWB vial came back 99 against a certificate saying 99.4, take that with a pinch of salt
i stayed on 1.7 for 13 months and never went to 2.4, appetite was already where i needed it, not advice obviously
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
mine faded too
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, n of 1 obviously
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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my 30 vial in 2.5ml gives 4mg/ml so 1.7 lands on 50 units, thats why i picked that volume
does moving my dose day by two days matter with a seven day half life
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2.4 is the ceiling
how many weeks before you noticed anything at 12
went too fast once
did anybody find a difference between GGPeps and pharmacy at the same 1
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right so changed my mind on the four week rule, i think it depends entirely on how the current dose feels
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
seven days ish
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
the appetite effect faded for me around 4 months and going up fixed it for a while
anyone compared their 2.5 vial dosing against the pen increments
i held at 0.25 for 4 months and it was the best decision i made
quick one moving my dose day by a day or two never did anything noticeable for me
is there a reason to hold at 1.7 rather than going to 2.4
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im at 10 and stuck, did anyone break a plateau without going up
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
slower worked better
how long till steady state, ive read the half life is about a week
is the plateau at 4 weeks normal or am i doing something wrong
five week steps worked better for me than four, purely on how the second week felt
held there too
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
whats the actual licensed ceiling, i keep seeing different numbers
does the licensed ceiling for weight differ from the diabetes one
what did SELECT actually measure, i see it quoted for everything
does the seven day half life mean the last two days are weaker
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
plateaus move
i dont think the plateau is a dose problem most of the time, but i cant prove that
sorry to jump in STEP is several trials, so saying STEP said x is usually wrong without a number after it
slightly off topic but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgsteady state is the bit people skip, judging a new dose after eight days tells you almost nothing
unrelated but compounded and brand felt the same to me at 0.25, which is one person and nothing more
dose day is sunday for me only because thats when i remember, not because sunday matters
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, anyway
SELECT wasnt weight, not advice obviously
while im here is the plateau usually appetite coming back or just the scale stopping